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首页> 外文期刊>BMJ Open Respiratory Research >CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study
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CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study

机译：Caspa（Papworth中的心脏结节病）改善了肺结节病患者心脏胁迫的诊断：术语课程议定书

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Introduction Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis. Echocardiography, ECG and Holter monitoring may be indicative but not diagnostic alone. Patients can present late with conduction defects, heart failure or sudden death. The CASPA (CArdiac Sarcoidosis in PApworth) study protocol aims to (1) use MRI to identify CS prevalence; (2) use speckle-tracking echocardiography, signal averaged ECG and Holter monitoring to look for diagnostic pathways; and (3) identify serum proteins which may be associated with CS.Methods and analysis Participants with pulmonary sarcoidosis (and no known cardiac disease) from Royal Papworth Hospital will have the following: cardiac MRI with late gadolinium, two-dimensional transthoracic echocardiography with speckle tracking, signal averaged ECG and 24-hour Holter monitor. They will provide a serum sample for brain natriuretic peptide levels and proteomics by liquid chromatography coupled to high-resolution mass spectrometry. All data will be collected on OpenClinica platform and analysed approximately 6 months after final patient recruitment.Ethics and dissemination The Camden & Kings Cross Research Ethics Committee approved the protocol (REC number: 17/LO/0667). Integrated Research Approval System (IRAS) 222?720. Dissemination of findings will be via conference presentations and submitted to peer-reviewed journals.
机译：引言结节病是一种多洋组织疾病，主要是影响肺部，但可以涉及心脏，导致心脏结石病（CS）。患者需要MRI /正电子发射断层扫描（PET）扫描进行诊断。超声心动图，ECG和HOLTER监测可以是指示性的，但不能单独诊断。患者可以延迟导致缺陷，心力衰竭或猝死。 CASPA（Papworth中的心脏结节病）研究协议旨在（1）使用MRI鉴定CS患病率; （2）使用散斑跟踪超声心动图，信号平均ECG和HOLTER监控寻找诊断途径; （3）鉴定血清蛋白，其可能与Cs.Methods和分析参与者来自皇家Papworth医院的肺酸肺病变（和已知的心脏病）将具有以下内容：心脏MRI与晚期钆，具有斑点的二维Transthoracic超声心动图跟踪，信号平均ECG和24小时HOLTER显示器。它们将通过液相色谱法偶联至高分辨率质谱，为脑利钠肽水平和蛋白质组学提供血清样本。所有数据都将收集在OpenClinica平台上，并在最终患者招聘后大约6个月分析。议案和传播Camden＆Mance Cross Research伦理委员会批准（REC编号：17 / LO / 0667）。综合研究批准系统（IRA）222？720。传播调查结果将通过会议介绍，并提交给同行评审期刊。

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