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首页> 外文期刊>BMC Veterinary Research >Auditory functional magnetic resonance imaging in dogs – normalization and group analysis and the processing of pitch in the canine auditory pathways
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Auditory functional magnetic resonance imaging in dogs – normalization and group analysis and the processing of pitch in the canine auditory pathways

机译：在狗的听觉功能磁共振成像 - 常规化和群体分析以及犬耳路中的音高处理

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Functional magnetic resonance imaging (fMRI) is an advanced and frequently used technique for studying brain functions in humans and increasingly so in animals. A key element of analyzing fMRI data is group analysis, for which valid spatial normalization is a prerequisite. In the current study we applied normalization and group analysis to a dataset from an auditory functional MRI experiment in anesthetized beagles. The stimulation paradigm used in the experiment was composed of simple Gaussian noise and regular interval sounds (RIS), which included a periodicity pitch as an additional sound feature. The results from the performed group analysis were compared with those from single animal analysis. In addition to this, the data were examined for brain regions showing an increased activation associated with the perception of pitch. With the group analysis, significant activations matching the position of the right superior olivary nucleus, lateral lemniscus and internal capsule were identified, which could not be detected in the single animal analysis. In addition, a large cluster of activated voxels in the auditory cortex was found. The contrast of the RIS condition (including pitch) with Gaussian noise (no pitch) showed a significant effect in a region matching the location of the left medial geniculate nucleus. By using group analysis additional activated areas along the canine auditory pathways could be identified in comparison to single animal analysis. It was possible to demonstrate a pitch-specific effect, indicating that group analysis is a suitable method for improving the results of auditory fMRI studies in dogs and extending our knowledge of canine neuroanatomy.
机译：功能磁共振成像（FMRI）是一种高级和经常使用的技术，用于研究人类的大脑功能，越来越多地在动物中。分析FMRI数据的关键元素是组分析，有效的空间标准化是先决条件。在目前的研究中，我们将标准化和组分析应用于麻醉术中的听觉功能MRI实验的数据集。实验中使用的刺激范例由简单的高斯噪声和常规间隔声音（RIS）组成，其包括作为附加声音特征的周期性间距。将进行组分析的结果与单动物分析的结果进行了比较。除此之外，针对脑区域检查数据，显示出与间距的感知相关的增加的激活。通过组分析，鉴定了匹配右上橄榄核，横向列扣和内胶囊的位置的显着激活，在单一动物分析中无法检测到。此外，发现了听觉皮质中的大量活性体素。 RIS条件（包括间距）与高斯噪声（没有间距）的对比显示在匹配左侧内外核细胞核的位置的区域中显示出显着效果。通过使用组分析，可以与单动物分析相比，可以鉴定沿着犬耳道途径的额外激活区域。有可能证明特异性效果，表明群体分析是改善犬犬听觉FMRI研究结果的合适方法，并延长了犬神经肿瘤的知识。

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