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首页> 外文期刊>BMC Pulmonary Medicine >Patterns of pleural pressure amplitude and respiratory rate changes during therapeutic thoracentesis
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Patterns of pleural pressure amplitude and respiratory rate changes during therapeutic thoracentesis

机译：胸腔压力幅度和呼吸速率在治疗胸腔周面期间变化

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Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the study was to assess the changes in pleural pressure amplitude (Pplampl) during the respiratory cycle and respiratory rate (RR) in patients undergoing pleural fluid withdrawal. The study included 23 patients with symptomatic pleural effusion. Baseline pleural pressure curves were registered with a digital electronic manometer. Then, the registrations were repeated after the withdrawal of consecutive portions of pleural fluid (200?ml up to 1000?ml and 100?ml above 1000?ml). In all patients the pleural pressure curves were analyzed in five points, at 0, 25%, 50%, 75% and 100% of the relative volume of pleural effusion withdrawn in particular patients. There were 11 and 12 patients with right sided and left sided pleural effusion, respectively (14?M, 9F, median age 68, range 46–85?years). The most common cause of pleural effusion were malignancies (20 pts., 87%). The median total volume of withdrawn pleural fluid was 1800 (IQR 1500–2400) ml. After termination of pleural fluid withdrawal Pplampl increased in 22/23 patients compared to baseline. The median Pplampl increased from 3.4 (2.4–5.9) cmH2O to 10.7 (8.1–15.6) cmH2O (p?
机译：虽然治疗胸腔穿刺术对肺功能和血气的影响有几项研究已经评估，胸水撤离的一些生理方面仍下落不明。该研究的目的是评估呼吸循环期间胸腔压力幅度（PPLAMPL）的变化以及患有胸腔液撤离的患者的呼吸循环和呼吸速率（RR）。该研究纳入23例有症状的胸腔积液。基线胸膜腔压力曲线与数字电子压力计注册。然后，胸膜液的连续部分的撤离后重复进行注册（200？毫升高达1000？ml和100？毫升千？毫升以上）。在所有患者胸膜压力曲线在五个点分析，在0，25％，50％，75％，特别是患者撤回胸腔积液的相对体积的100％。有11个12例，右胸和左双面胸腔积液，分别为（14？m，9F，平均年龄68，范围46-85？年）。胸腔积液最常见的原因是恶性肿瘤（20分，87％）。抽出胸膜液的中位总体积为1800（IQR 1500至2400年）毫升。胸水撤离结束后Pplampl在22/23患者相比增加基线。中位数PPLAMPL从3.4（2.4-5.9）CMH2O增加到10.7（8.1-15.6）CMH2O（P？<β0.0001）。的Pplampl变化三种模式进行了鉴定。虽然RR变化模式进行更加多样化，RR之间在基线和最后的测量点则显著上升发现（P 2 =？0.0097）。总之，治疗胸腔与呼吸循环中Pplampl显著变化有关。在绝大多数患者Pplampl胸水撤离期间将稳步增长。也有增加RR。在进一步的研究中应阐明这些变化的重要性。 ClinicalTrial.gov，注册号：NCT02192138，注册登记日期：2014年7月1日。

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