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A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease

机译：胃食管反流疾病荟萃分析的系统综述及慢性阻塞性肺病的恶化

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Gastroesophageal reflux disease (GERD) was suggested to be associated with exacerbations of chronic obstructive pulmonary disease (COPD) in recent years. The aim of this study was to examine the association between GERD and COPD exacerbation through a meta-analysis. Databases including EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched with a systematic searching strategy for original articles, published until Jan 2019, without language restriction. A total of 13,245 patients from 10 observational articles were included in the meta-analysis. The meta-analysis indicated that GERD is associated with increased risk of COPD exacerbation (OR: 5.37; 95% CI 2.71–10.64). Patients with COPD and GERD had increased number of exacerbation (WMD: 0.48; 95% CI: 0.31 to 0.65). The meta-analysis showed that there was a significant correlation between GERD and COPD exacerbation.
机译：近年来，建议胃食管反流疾病（GERD）与慢性阻塞性肺病（COPD）的恶化有关。本研究的目的是通过META分析检查GERD和COPD加剧之间的关联。在2019年1月发布的系统搜索策略中搜索了包括Embase，Medline和Cochrane中央登记术的数据库，并在2019年1月，没有语言限制。在Meta分析中，共有来自10篇观察制品的13,245名患者。 Meta分析表明GERD与COPD Exacterbation的风险增加有关（或5.37; 95％CI 2.71-10.64）。具有COPD和GERD的患者的加重数量增加（WMD：0.48; 95％CI：0.31至0.65）。 Meta分析表明，GERD和COPD加剧之间存在显着相关性。

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