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首页> 外文期刊>BMC Anesthesiology >The effect of intraoperative lidocaine infusion on opioid consumption and pain after totally extraperitoneal laparoscopic inguinal hernioplasty: a randomized controlled trial
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The effect of intraoperative lidocaine infusion on opioid consumption and pain after totally extraperitoneal laparoscopic inguinal hernioplasty: a randomized controlled trial

机译：术中Lidocaine输注对完全腹腔镜腹腔镜疝膜成形术后阿片类药物消耗和疼痛的影响：随机对照试验

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As a component of multimodal analgesia, the administration of systemic lidocaine is a well-known technique. We aimed to evaluate the efficacy of lidocaine infusion on postoperative pain-related outcomes in patients undergoing totally extraperitoneal (TEP) laparoscopies inguinal hernioplasty. In this randomized controlled double-blind study, we recruited 64 patients to receive either lidocaine 2% (intravenous bolus 1.5?mg. kg ??1 followed by an infusion of 2?mg. kg??1. h??1), or an equal volume of normal saline. The infusion was initiated just before the induction of anesthesia and discontinued after tracheal extubation. The primary outcome of the study was postoperative morphine equivalent consumption up to 24?h after surgery. Secondary outcomes included postoperative pain scores, nausea/vomiting (PONV), sedation, quality of recovery (scores based on QoR-40 questionnaire), patient satisfaction, and the incidence of chronic pain. The median (IQR) cumulative postoperative morphine equivalent consumption in the first 24?h was 0 (0–1) mg in the lidocaine group and 4 [1–8] mg in the saline group (p??0.001). Postoperative pain intensity at rest and during movement at various time points in the first 24?h were significantly lower in the lidocaine group compared with the saline group (p??0.05). Fewer patients reported PONV in the lidocaine group than in the saline group (p??0.05). Median QoR scores at 24?h after surgery were significantly better in the lidocaine group (194 (194–196) than saline group 184 (183–186) (p??0.001). Patients receiving lidocaine were more satisfied with postoperative analgesia than those receiving saline (p?=?0.02). No difference was detected in terms of postoperative sedation and chronic pain after surgery. Intraoperative lidocaine infusion for laparoscopic TEP inguinal hernioplasty reduces opioid consumption, pain intensity, PONV and improves the quality of recovery and patient satisfaction. ClinicalTrials.gov- NCT02601651. Date of registration: November 10, 2015.
机译：作为多模式镇痛的组分，系统性利多卡因的给药是一种众所周知的技术。我们的旨在评估利多卡因输注对接受完全腹膜腹腔镜腹腔镜疝术术治疗术后患者术后疼痛相关结果的疗效。在这种随机对照双盲研究中，我们招募了64名患者接受LIDOCAINE 2％（静脉注射的推注1.5？MG。kg ?? 1，然后输注2μm。kg ?? 1），或等体积的正常盐水。在诱导麻醉前并在气管拔管后停止的发生。该研究的主要结果是手术后的术后吗啡当量消耗，高达24℃。二次结果包括术后疼痛评分，恶心/呕吐（PONV），镇静，恢复质量（基于QOR-40问卷的分数），患者满意度和慢性疼痛的发生率。在Lidocaine组中的第24〜H中的中位数（IQR）累积术后吗啡当量消耗为0（0-1）毫克，盐碱中的4 [1-8] Mg（p≤0.001）。与盐碱组相比，Lid Caine Group在Lidocaine组中，在第一个24〜2的各个时间点的术后疼痛强度和在运动中的各种时间点（P？<β0.05）。较少的患者报告LIDOCAINE组的PONV比盐碱组（P？<？0.05）。在Lidocaine Group（194（194-196）比盐水组（183-186）（p？<0.001）中，手术后24℃的中位Qor分数明显更好接受盐水的那些（p？= 0.02）。在手术后术后镇静和慢性疼痛的方面没有差异。腹腔镜Tep腹膜疝的术中Lidocaine输注可降低阿片类药物消耗，疼痛强度，庞大，提高恢复和患者的质量满意度。ClinicalTrials.gov-nct02601651。注册日期：2015年11月10日。

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