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首页> 外文期刊>BMC Infectious Diseases >Incidence and predictors of tuberculosis occurrence among adults on antiretroviral therapy at Debre Markos referral hospital, Northwest Ethiopia: retrospective follow-up study
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Incidence and predictors of tuberculosis occurrence among adults on antiretroviral therapy at Debre Markos referral hospital, Northwest Ethiopia: retrospective follow-up study

机译：埃塞俄比亚西北地区抗逆转录病毒治疗成人抗逆转录病毒治疗抗逆转录病毒治疗的发病率和预测因子：回顾性随访研究

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In resource limited settings, Tuberculosis (TB) is a major cause of morbidity and mortality among patients on antiretroviral treatment. Ethiopia is one of the 30 high TB burden countries. TB causes burden in healthcare system and challenge the effectiveness of HIV care. This study was to assess incidence and predictors of Tuberculosis among adults on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia, 2019. Institution based retrospective follow up study was conducted among adults on ART newly enrolled from 2014 to 2018 at Debre Markos Referral Hospital. Simple random sampling technique was used to select patients chart. Data was entered to EPI- INFO version 7.2.2.6 and analyzed using Stata 14.0. Tuberculosis incidence rate was computed and described using frequency tables. Both bivariable and multivariable Cox proportional hazard models was fitted to identify predictors of TB. Out of the 536 patients chart reviewed, 494 patient records were included in the analysis. A total of 62 patients developed new TB cases during the follow up period of 1000.22 Person Years (PY); which gives an overall incidence rate of 6.19 cases per 100 PY (95% CI: 4.83–7.95). The highest rate was seen within the first year of follow up. After adjustment base line Hemoglobin ?10?g/dl (AHR?=?5.25; 95% CI: 2.52–10.95), ambulatory/bedridden patients at enrolment (AHR?=?2.31; 95% CI: 1.13–4.73), having fair or poor ART adherence (AHR?=?3.22; 95% CI: 1.64–6.31) were associated with increased risk of tuberculosis whereas taking Isoniazid Preventive Therapy (IPT) (AHR?=?0.33; 95% CI: 0.12–0.85) were protective factors of TB occurrence. TB incidence was high among adults on ART especially in the first year of enrollment to ART. Low hemoglobin level, ambulatory or bedridden functional status, non-adherence to ART and IPT usage status were found to be independent predictors. Hence, continuous follow up for ART adherence and provision of IPT has a great importance to reduce the risk of TB.
机译：在资源有限的环境中，结核病（TB）是抗逆转录病毒治疗患者发病率和死亡率的主要原因。埃塞俄比亚是30个高结核病负担国家之一。 TB导致医疗保健系统的负担，并挑战艾滋病毒护理的有效性。本研究是在2019年西北埃塞俄比亚德布勒斯科斯推荐医院评估成人抗逆转录病毒治疗抗逆转录病毒治疗的结核病的发病率和预测因子。基于机构的回顾性跟进研究是在2014年至2018年在德布雷马克斯推荐医院进行的成年人进行的成年人进行。简单的随机采样技术用于选择患者图表。数据已输入到Epi-Info 7.2.2.6版本，并使用Stata 14.0进行分析。使用频率表计算和描述结核病发生率。双方和多变量的Cox比例危险模型均可识别TB的预测因子。在536名患者中，审查的图表，分析中包含494名患者记录。共有62名患者在1000.22人的后续期间开发了新的结核病病例（PY）;这给出了每100 pY的6.19例的总发病率（95％CI：4.83-7.95）。在跟进的第一年内看到了最高率。调整碱基线血红蛋白<？10？G / DL（AHR？= 5.25; 95％CI：2.52-10.95），注册的动态/卧床患者（AHR？= 2.31; 95％CI：1.13-4.73），具有公平或薄弱的奉献术（AHR？= 3.22; 95％CI：1.64-6.31）与结核病的风险增加有关，而服用异烟体预防治疗（AHR？= 0.33; 95％CI：0.12-0.85 ）是TB发生的保护因素。 TB发病率在艺术上的成年人中很高，特别是在入学艺术的第一年。发现低血红蛋白水平，动态或卧床功能的状态，不遵守艺术和IPT使用状态是独立的预测因子。因此，持续跟进艺术遵守和提供IPT的规定具有重要意义，以降低结核病的风险。

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