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Rubella IgM epidemiology in the pre-rubella vaccination era in Uganda

机译:乌干达前风疹疫苗接种时代的风疹IgM流行病学

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Control of Rubella and Congenital Rubella Syndrome using vaccination has shown great success in the America’s. Uganda is due to introduce the Rubella vaccine however the magnitude of transmission is not well documented. Therefore this study was done to determine IgM sero-prevalance for Rubella in order to help monitor vaccine effectiveness post introduction of the vaccine in routine vaccination programme. A retrospective review of suspected measles cases data for the reporting period January 2007 to December 2016 in Uganda was Done. rubella IgM testing was done on 15,296 of the cases and the data was analyzed using STATA version 13. In total 15,296 cases were tested and 4255 (27.8%) tested positive and among females aged 15-49?years 88 out of 322 (27%) tested positive. The age distribution range was 0–80?years, rubella IgM positivity was reported in all the 15 regions of Uganda and throughout the ten year period in every month. Age group 5–15?years had OR 2.5 p-value ?0.001 of being rubella IgM positive compared to age??5?years and testing measles IgM negative OR 6.3 p-value ?0.001. Rubella is endemic in Uganda and although rubella IgM positivity is highest in the age 5-15?years even the younger, older and women of reprodutive age are affected. This means the risk of Congenital Rubella Syndrome is high hence the need to introduce the rubella vaccine for infants and pregnant mothers and continued surveillance to enhance its control.
机译:使用疫苗接种的对风疹和先天性风疹综合征的控制表现出巨大的成功。乌干达是由于引入了风疹疫苗,但传动的幅度并不充分记录。因此,完成该研究以确定风疹的IgM血清普遍,以帮助监测疫苗效果在常规疫苗接种程序中引入疫苗。对乌干达的报告期间至2016年12月的疑似麻疹病例数据进行了回顾性审查。 Rubella IgM测试是在15,296的情况下进行的,使用STATA 13版分析数据。总计15,296例,4255例(27.8%)测试阳性,女性在15-49岁以下的女性中,322岁以下(27%) )测试阳性。年龄分布范围为0-80岁,在乌干达的所有15个地区和每个月的整个十年内报告了风疹IgM积极性。年龄组5-15?多年或2.5个p值<?0.001是风疹IgM阳性与年龄相比阳性?<?5?岁月和测试麻疹IgM阴性或6.3 p值<0.001。风疹是乌干达的地方,虽然风疹IgM积极性在5-15岁的时候是最高的,但渐龄,年龄较大的年龄和女性也受到影响。这意味着先天性风疹综合征的风险很高,因此需要引入婴儿和怀孕母亲的风疹疫苗,并继续监测,以提高其控制。

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