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首页> 外文期刊>BMC Infectious Diseases >Phylogenetic analysis highlights the role of older people in the transmission of HIV-1 in Fuyang, Anhui Province, China
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Phylogenetic analysis highlights the role of older people in the transmission of HIV-1 in Fuyang, Anhui Province, China

机译：系统发育分析突出了老年人在中国安徽省富阳富阳艾滋病毒-1传播中的作用

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The proportion of older HIV-1 infected people in China has increased rapidly in recent years. Elucidation of the transmission characteristics of this high-risk population subgroup is helpful for the development of tailored interventions. A phylogenetic analysis was performed that uses available HIV-1 pol sequences amplified with nested RT-PCR from plasma samples of all newly diagnosed participants spanning from October 2017 to September 2018 in Fuyang, Anhui Province. Transmission clusters were identified as two or more sequences that shared a corresponding node with an aLRT-SH value ≥90 in the maximum-likelihood phylogenetic tree and had an overall mean genetic distance of ≤1.5%. A local transmission cluster was defined as a cluster that had more than 80% of its sequences from Fuyang. The role of older people in local HIV-1 transmission was determined using an integration of molecular and demographic data. Of 362 available sequences, 14 subtypes, and 28 local transmission clusters were identified. It was found that the proportion of older people in the local transmission cluster (69/77, 89.61%) was much higher than that of younger people (46/114, 40.35%) (χ2 test, P??0.05). By combining phylogenetic analyses with demographic data, more detailed information was provided about the local transmission structure in Fuyang. These findings suggested that older people play an important role in local transmission, and more tailored interventions for this population subgroup are urgently needed.
机译：近年来，中国较大的HIV-1受感染的人的比例迅速增加。阐明这种高风险群体群的传输特性有助于制定量身定制的干预措施。进行了系统发育分析，其使用从2017年10月至2018年10月到2018年9月，从2017年10月到2018年9月，在安徽省富阳的所有新诊断的参与者的血浆样本中，可用的HIV-1 POL序列。将传输簇鉴定为两个或更多个序列，其在最大似然性系统发育树中与ALT-SH值≥90共享相应节点，并且总体平均遗传距离≤1.5％。本地传输群集被定义为阜阳超过80％的群集。使用分子和人口统计数据的整合确定老年人在局部HIV-1传输中的作用。鉴定了362个可用序列，14个亚型和28个本地传输群集。有人发现，当地传输集群（69/77,89.61％）的老年人比例远高于年轻人（46/114,40.35％）（χ2检验，p ?? 0.05）。通过将系统发育分析与人口统计数据相结合，提供了阜阳局部传输结构的更详细信息。这些调查结果表明，老年人在局部传输中发挥着重要作用，迫切需要更加定制的人口亚组的干预措施。

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