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首页> 外文期刊>BMC Infectious Diseases >A randomized controlled trial study of the acceptability, feasibility, and preliminary impact of SITA (SMS as an Incentive To Adhere): a mobile technology-based intervention informed by behavioral economics to improve ART adherence among youth in Uganda
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A randomized controlled trial study of the acceptability, feasibility, and preliminary impact of SITA (SMS as an Incentive To Adhere): a mobile technology-based intervention informed by behavioral economics to improve ART adherence among youth in Uganda

机译：随机对照试验研究SITA的可接受性，可行性和初步影响（SMS作为遵守的激励）：行为经济学通知基于移动技术的干预，以改善乌干达青年之间的艺术遵守情况

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Background: Studies report serious adherence problems among youth (individuals age 15–24 years of age) in Uganda.Recent growth in mobile phone ownership has highlighted the potential of using text-based interventions to improveantiretroviral treatment (ART) adherence among Ugandan youth. We piloted a randomized controlled trial of a text-basedintervention providing weekly real-time antiretroviral adherence feedback, based on information from a smart pill box, toHIV-positive Ugandan youth. In this paper, we report the acceptability, feasibility, and preliminary impact of the intervention.Methods: We randomized participants to a control group, or to receive messages with information on either their ownadherence levels (Treatment 1 - T1), or their own adherence and peer adherence levels (Treatment 2 – T2). Weconducted six focus groups from December 2016 to March 2017 with providers and youth ages 15–24, double coded130 excerpts, and achieved a pooled Cohen’s Kappa of 0.79 and 0.80 based on 34 randomly selected excerpts.Results: The quantitative and qualitative data show that the intervention was deemed acceptable and feasible. Aftercontrolling for baseline adherence, the T1 group had 3.8 percentage point lower adherence than the control group(95% CI -9.9, 2.3) and the T2 group had 2.4 percentage points higher adherence than the control group (95% CI -3.0,7.9). However, there was an increasing treatment effect over time for the T2 group with the largest effect towards theend of the study; a 2.5 percentage point increase in the initial 9-weeks that grows steadily to 9.0 percentage points bythe last 9-weeks of the study. We find negative treatment effects for T1 in 3 of the 4 9-week intervals. This pilot studywas not designed to detect statistically significant differences.Conclusions: Improving youth’s adherence by supplementing information about their adherence with informationabout the adherence of peers is a promising new strategy that should be further evaluated in a fully-powered study.Providing one’s own adherence information alone appears to have less potential.
机译：背景：研究报告乌干达中的青年（15-24岁的人）的严重依从性问题。移动电话所有权的增长强调了利用基于文本的干预措施改变乌干达青年之间的侵犯性的潜力（艺术）遵守。我们试图基于智能药丸盒，往返乌干达青年的信息提供每周实时抗逆转录血管遵守反馈的随机对照试验。在本文中，我们报告了干预的可接受性，可行性和初步影响。方法：我们将参与者随机化到对照组，或者通过关于其自身的信息（治疗1 - T1）或自己的遵守信息来接收信息和同伴粘附水平（治疗2 - T2）。从2016年12月到2017年12月到2017年12月的六个焦点小组与15-24岁，双重编码130摘录，并达到了0.79和0.80的汇集科恩的Kappa，基于34次随机选择的摘录。结果：定量和定性数据显示干预被认为是可接受的和可行的。接受基线依从性的可逆性后，T1组比对照组（95％CI -9.9,2.3）和T2组比对照组更高的粘附组（95％CI -3.0,7.9），T1组具有3.8个百分点。然而，随着T2群体的时间随着时间的推移而增加了对研究的最大影响;最初的9周内增加了2.5个百分点，稳步增长至第9周的研究中的9.0个百分点。我们在4个9周间隔中的3个中找到T1的负处理效果。这一导频学习不旨在检测统计上显着的差异。结论：通过补充有关他们的遵守信息的信息，提高对象的遵守对同行的遵守是一个有前途的新战略，应该进一步在完全有源的研究中进一步评估。管理自己的遵守信息单独似乎有较少的潜力。

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