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首页> 外文期刊>BMC Infectious Diseases >Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study
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Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study

机译：武汉市Covid-19 143例疾病严重程度与生化特征的相关分析：描述性研究

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BACKGROUND:Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.METHODS:In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.RESULTS:Significantly, disease severity was associated with age (r?=?0.458, P??0.001), comorbidities (r?=?0.445, P??0.001), white cell count (r?=?0.229, P?=?0.006), neutrophil count (r?=?0.238, P?=?0.004), lymphocyte count (r?=?-?0.295, P??0.001), albumin (r?=?-?0.603, P??0.001), high-density lipoprotein cholesterol (r?=?-?0.362, P??0.001), serum potassium (r?=?-?0.237, P?=?0.004), plasma glucose (r?=?0.383, P??0.001), total bilirubin (r?=?0.340, P??0.001), serum amyloid A (r?=?0.58, P??0.001), procalcitonin (r?=?0.345, P??0.001), C-reactive protein (r?=?0.477, P??0.001), lactate dehydrogenase (r?=?0.548, P??0.001), aspartate aminotransferase (r?=?0.342, P??0.001), alanine aminotransferase (r?=?0.264, P?=?0.001), erythrocyte sedimentation rate (r?=?0.284, P?=?0.001) and D-dimer (r?=?0.477, P 0.001) .CONCLUSIONS:With the following parameters such as age??52?years, C-reactive protein ?64.79?mg/L, lactate dehydrogenase ?245?U/L, D-dimer ?0.96 μg/mL, serum amyloid A??100.02?mg/L, or albumin 36?g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.
机译：背景：2019年冠状病毒疾病（Covid-19）是由武汉出现的严重急性呼吸综合征冠状病毒2（SARS-COV-2）引起的新型传染病，并迅速遍布全球。 Covid-19患者危重病人的死亡率高。本研究分析了轻度和严重患者之间的临床和生化参数，有助于鉴定严重或关键患者的早期。在这种单一中心，横断面研究，143名患者分为轻度/中度和断开/关键群体。分析了疾病关键性与临床特征与外周血生物化学标志物之间的相关性。通过ROC曲线推测临界病患者的截止值。结果：显着，疾病严重程度与年龄有关（R？= 0.458，P？<0.001），合并症（R？= 0.445，P？< ？0.001），白细胞计数（r？= 0.229，p？= 0.006），中性粒细胞计数（r？= 0.238，p？= 0.004），淋巴细胞计数（r？=？ - ？0.295，p？0.295，p？0.295，p？0.295 <？0.001），白蛋白（R？=α - 0.603，p？<〜0.001），高密度脂蛋白胆固醇（R？=α - 0.362，p？<0.001），血清钾（R？=？ - ？0.237，p？= 0.004），等离子体葡萄糖（r？= 0.383，p？<〜0.001），总胆红素（R？= 0.340，p？<0.001），血清淀粉样蛋白a（r？= ？0.58，p？<〜0.001），procalcitonin（r？= 0.345，p？<〜0.001），C-反应蛋白（R？= 0.477，p？<0.001），乳酸脱氢酶（R？=？ 0.548，p？<0.001），天冬氨酸氨基转移酶（R？= 0.342，p≤≤0.001），丙氨酸氨基转移酶（R？= 0.264，P？= 0.001），红细胞沉降率（R？= 0.284 ，p？= 0.001）和D-二聚体（R？= 0.477，P <0.001）。结论：具有以下参数，如年龄？>？52岁，C-反应蛋白>？64.79？m g / l，乳酸脱氢酶>α245？U / L，D-二聚体>α.0.96μg/ ml，血清淀粉样蛋白A〜α>？100.02？mg / L，或白蛋白<36μg/ l，进展的covid- 19应密切关注和可能预防临时阶段。淋巴细胞计数，血清钾，高密度脂蛋白胆固醇和ProCalcitonin也可以是预后指示剂。

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