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首页> 外文期刊>Brazilian Journal of Cardiovascular Surgery >Mean Platelet Volume-to-Platelet Count Ratio, Mean Platelet Volume-to-Lymphocyte Ratio, and Red Blood Cell Distribution Width-Platelet Count Ratio as Markers of Inflammation in Patients with Ascending Thoracic Aortic Aneurysm
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Mean Platelet Volume-to-Platelet Count Ratio, Mean Platelet Volume-to-Lymphocyte Ratio, and Red Blood Cell Distribution Width-Platelet Count Ratio as Markers of Inflammation in Patients with Ascending Thoracic Aortic Aneurysm

机译：平均血小板体积与血小板计数比，平均血小板体积对淋巴细胞比，红细胞分布宽度 - 血小板计数与升胸主动脉动脉瘤患者炎症的标志物

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Objective: Ascending thoracic aortic aneurysm (ATAA), seen in adults, is an important cause of morbidity and mortality. In this study, we aimed to evaluate the levels of mean platelet volume (MPV), mean platelet volume-to-platelet count ratio (MPVPCR), mean platelet volume-to-lymphocyte ratio (MPVLR), and red cell distribution width platelet count ratio (RDWPCR) in patients with thoracic aortic aneurysm. Methods: 105 patients admitted to the emergency department were diagnosed with thoracic aortic aneurysm between January and December 2014, and 100 healthy individuals were involved in this retrospective study. MPV, MPVLR, MPVPCR and RDWPCRs were calculated at the time of admission. Results: Platelet and lymphocyte levels were found to be significantly lower in the patient group when compared to the healthy group (P0.001, P0.001, respectively), while MPV, MPVPCR, MPVLR and RDWPCR were found to be significantly higher (P0.001, P0.001, P0.001, and P=0.013, respectively). In the patient group, the high-sensitivity C-reactive protein was significantly higher (P0.001), and the neutrophil (P=0.062) was also higher. In ROC analysis, MPVPCR had the highest sensitivity (80%) and RDWPCR had the highest specificity (72%). Conclusion: The results for MPV, MPVPCR, MPVLR and RDWPCR can be evaluated as useful parameters in the emergency clinical approach in the evaluation of inflammatory activity in ATAA patients. More extensive studies are required to address the role of these parameters in determining the severity of the disease.
机译：目的：在成人中看到的胸主动脉瘤（ATAA）是发病率和死亡率的重要原因。在这项研究中，我们旨在评估平均血小板体积（MPV）的水平，平均血小板体积与血小板计数比（MPVPCR），平均血小板体积对淋巴细胞比（MPVLR）和红细胞分布宽度血小板计数胸主动脉瘤患者的比例（RDWPCR）。方法：进入急诊科的105名患者被诊断为2014年1月至12月之间的胸主动脉瘤，并参与了这项回顾性研究的100个健康个体。在入场时计算MPV，MPVLR，MPVPCR和RDWPCR。结果：与健康组相比，患者组中的血小板和淋巴细胞水平显着降低（分别为P <0.001，P <0.001），而发现MPV，MPVPCR，MPVLR和RDWPCR显着更高（P <0.001，p <0.001，p <0.001和P = 0.013）。在患者组中，高敏感性C反应蛋白显着升高（P <0.001），中性粒细胞（P = 0.062）也更高。在ROC分析中，MPVPCR具有最高的敏感性（80％），RDWPCR具有最高的特异性（72％）。结论：MPV，MPVPCR，MPVLR和RDWPCR的结果可评估为ATAA患者炎症活性评估的应急临床方法中的有用参数。需要更广泛的研究来解决这些参数在确定疾病的严重程度方面的作用。

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