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首页> 外文期刊>BMC Musculoskeletal Disorders >Does peak bone mass correlate with peak bone strength? Cross-sectional normative dual energy X-ray absorptiometry data in 1052 men aged 18–28?years
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Does peak bone mass correlate with peak bone strength? Cross-sectional normative dual energy X-ray absorptiometry data in 1052 men aged 18–28?years

机译：峰骨质量是否与峰值骨强度相关？ 1052名男性18-28岁的男性横截面规范双能量X射线吸收仪数据

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Areal bone mineral density (aBMD) estimated by dual-energy X-ray absorptiometry (DXA) is used to estimate peak bone mass, define osteoporosis and predict fracture. However, as aBMD is calculated as bone mineral content (BMC) divided by the scanned area, aBMD displays an inverse relationship with bone size. In a skeleton that is increasing in size, this is a problem, as bone size is an independent factor that determines bone strength. It could therefore be questioned whether peak aBMD is the period with greatest bone strength, a period that in the hip then would occur in ages 16-19. The aim of this study was to evaluate whether there are changes in bone size in men after age 18 that may influence peak bone strength. Another aim was to provide updated normative DXA data. We scanned left femoral neck by DXA in a cross-sectional study with a population-based selection of 1052 men aged 18-28, and then registered bone mineral content (BMC, gram), aBMD (gram/cm2) and bone area (cm2) in each one-year age group. We performed analyses of variance (ANOVA) to evaluate whether there were differences in these traits between the age groups. We then used Pearson's correlation analyses to test for trends with ageing after peak bone mass was reached. We found the highest absolute femoral neck aBMD at age 19, with statistically significant differences between the one-year age groups in BMC, aBMD, and bone area (all p??0.05). From peak bone mass onwards (n?=?962), there are negative correlations between age and BMC (r?=?-?0.07; p??0.05) and age and aBMD (r?=?-?0.12; p??0.001), and positive correlation between age and bone area (r?=?0.06; p??0.05). As femoral neck bone size in young adult men becomes larger after peak bone mass, it could be questioned whether DXA estimated peak aBMD correlates with peak bone strength. We infer that aBMD must be interpreted with care in individuals with a growing skeleton, since skeletal strength may then increase, in spite of decreasing aBMD. This should be taken into account when performing DXA measurements in these ages.
机译：通过双能X射线吸收测定（DXA）估计的区域骨矿物密度（ABMD）用于估计峰骨质量，限定骨质疏松症和预测骨折。然而，由于ABMD计算为骨矿物含量（BMC）除以扫描区域，ABMD显示与骨骼大小的反向关系。在尺寸增加的骨架中，这是一个问题，因为骨骼大小是决定骨强度的独立因素。因此，可以质疑峰值ABMD是否是骨骼强度最大的时期，那么臀部的时期将在16-19岁以上发生。本研究的目的是评估可能影响峰值骨强度的18岁以后男性骨骼大小的变化。另一个目标是提供更新的规范性DXA数据。我们在横截面研究中扫描左侧股骨颈，横断面研究，群体的18-28岁的1052岁男性选择，然后注册骨矿物质含量（BMC，GRAM），ABMD（克/厘米）和骨区（CM2 ）在每个一年的年龄组中。我们对方差（ANOVA）进行了分析，以评估年龄组之间这些特征是否存在差异。然后，我们使用Pearson的相关性分析来测试达到峰值骨质量后随老化的趋势。我们在19岁时发现了最高的绝对股骨颈部ABMD，BMC，ABMD和骨骼区的一年年龄组（所有P？<0.05）之间的一年年龄群之间存在统计学意义。从峰值骨质量开始（n？= 962），年龄和bmc之间存在负相关（r？=Δ - 07; p？<0.05）和年龄和abmd（r？=？ - ？0.12; p ？<？0.001），年龄和骨骼区域之间的正相关（R？= 0.06; p？<0.05）。由于股骨骨骼骨骼骨骼大小在骨质骨质肿块后变大，因此DXA估计峰值ABM与峰骨强度相关。我们推断ABMD必须用生长骨骼的个体进行护理，因为尽管ABMD降低，但骨骼强度可能会增加。在这些年龄段进行DXA测量时，应考虑这一点。

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