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首页> 外文期刊>BMC Nephrology >Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis
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Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis

机译：低骨质和血清RANKL和肾血清患者血清RANKL和OPG之间的关联

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Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This study aimed to evaluate the relation between serum OPG, RANKL concentration, and bone mineral density (BMD) in patients with kidney stone disease. Forty-four nephrolithiasis patients with either low bone mass or normal BMD (considered control group) were enrolled in this study. BMD was measured at lumbar spine (L1-L4) and femoral neck by dual-energy X-ray absorptiometry (DEXA). The serum OPG and RANKL were determined using the ELISA method. The median levels of serum OPG were significantly higher in nephrolithiasis patients with low bone mass compared to the nephrolithiasis patients with normal BMD (3.9?pmol/l versus 3.1?pmol/l; P?=?0.03), respectively. Negative correlation was detected between bone densities of femoral neck and OPG in patients with nephrolithiasis (r?=??.0344, P?=?0.02). The present study showed that high serum fasting OPG levels may be indicative of femoral neck BMD in patients with nephrolithiasis.
机译：肾血红病是骨质增生和骨质疏松症的危险因素。核因子Kappab配体（RANKL）和骨盆素（OPG）的受体激活剂调节骨重塑和骨质细胞发生。本研究旨在评估肾结石疾病患者血清OPG，RANKL浓度和骨密度（BMD）之间的关系。本研究招生了44例具有低骨质量或正常BMD（考虑对照组）的肾血症患者。通过双能X射线吸收度（DEXA）在腰椎（L1-L4）和股骨颈下测量BMD。使用ELISA方法确定血清OPG和RANKL。与正常BMD的肾血管患者相比，肾小滴血症患者中位水平的血清血清患者的中位水平分别分别与肾脏病患者相比分别为肾骨质量低在肾血症患者骨颈和OPG的骨密度之间检测到负相关（R？=Δ?0344，p？0.02）。本研究表明，血清禁食的高血清腹腔水平可指示肾血红素患者股骨颈BMD。

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