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首页> 外文期刊>BMC Pregnancy and Childbirth >Association between pre-pregnancy calcium intake and hypertensive disorders during the first pregnancy: the Japan environment and children’s study
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Association between pre-pregnancy calcium intake and hypertensive disorders during the first pregnancy: the Japan environment and children’s study

机译：在第一次怀孕期间孕前钙摄入和高血压障碍之间的关联：日本环境与儿童研究

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BACKGROUND:Determining the appropriate preconception care to reduce the occurrence of hypertensive disorder of pregnancy (HDP) remains a challenge in modern obstetrics. This study aimed to examine the association between pre-pregnancy calcium (Ca) intake and HDP in normotensive primiparas.METHODS:We used data from the Japan Environment Children's study (JECS), which is the largest birth cohort study. A total of 33,894 normotensive Japanese primiparas were recruited for JECS between January 2011 and March 2014. Participants were categorized into five groups according to pre-pregnancy Ca intake quintiles (Q1 and Q5 were the lowest and highest Ca intake groups, respectively) to compare their basic background and obstetrics outcome. Multiple logistic regressions were performed to identify the effect of pre-pregnancy Ca intake on HDP, early onset HDP, and late-onset HDP, using Ca intake thresholds of 500, 550, 650, 700, 1000, 1500, and 1500?mg.RESULTS:We found significant differences in maternal background among the Ca intake groups; in particular, there were more participants with low socioeconomic status, indicated by low education level and low household income, and smokers in the lowest Ca intake group. Multiple logistic regression did not show any significant difference with regard to HDP, early onset HDP, and late-onset HDP in each Ca intake threshold.CONCLUSIONS:Despite considerable recommendations concerning Ca intake for women of reproductive age, the present study indicates that pre-pregnancy Ca intake was not associated with an increased risk of new-onset hypertension among primiparas during pregnancy. Further studies examining the effect of other pre-pregnancy dietary factors on obstetric outcomes should be considered in the formulation of earlier preventive strategies for primiparas.
机译：背景：确定适当的先入为主护理，以减少怀孕高血压病症（HDP）的发生仍然是现代妇产病的挑战。本研究旨在审查妊娠前钙（CA）摄入和HDP之间的关联。方法：我们使用来自日本环境儿童学习（JEC）的数据，这是最大的出生队列研究。在2011年1月至2014年3月期间招募了33,894次正常的日本初级贴版草案。根据怀孕前的CA Intrake Quintiles（Q1和Q5分别是最低和最高的CA Intrake组，参与者分为五组，分别比较基本背景和产科结果。进行多元逻辑回归以鉴定HDP，早期发作HDP和晚期发作HDP上的妊娠前CA摄入的影响，使用500,550,650,700,1000,1500和1500？MG的CA进气阈值。结果：我们在加入组中发现了母体背景的显着差异;特别是，社会经济地位具有更低的参与者，由低教育水平和低家庭收入以及最低CA Intrake组的吸烟者表示。多个逻辑回归没有显示关于HDP，早期发作HDP和在每个CA Intake阈值中的延迟发作HDP的任何显着差异。结论：尽管对生殖年龄的妇女有关CA摄入量的大量建议，但本研究表明预先怀孕Ca Intake与怀孕期间Priuiparas新发病高血压的风险增加无关。进一步研究检查其他妊娠膳食因素对产科结果的影响，应在制​​定初期预防策略的priparas方面进行。

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