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首页> 外文期刊>Cancer Cell International >Expression and clinicopathological significance of miR-193a-3p and its potential target astrocyte elevated gene-1 in non-small lung cancer tissues
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Expression and clinicopathological significance of miR-193a-3p and its potential target astrocyte elevated gene-1 in non-small lung cancer tissues

机译：miR-193a-3p及其潜在靶星形胶质细胞升高基因-1在非小肺癌组织中的表达及临床病理学意义

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Aberrant expression of miR-193a-3p and astrocyte elevated gene-1 (AEG-1) have been revealed to be related to the tumorigenesis of various cancers, including non-small cell lung cancer (NSCLC). However, the significance of miR-193a-3p and its correlation with AEG-1 in NSCLC has not been explored. The purpose of this study was to evaluate the association between miR-193a-3p and AEG-1 and their relationship with the clinicopathological features in NSCLC patients. Via online in silico prediction, complementary sequences were found between miR-193a-3p and the 3′-untranslated region of AEG-1. Three independent cohorts were applied in the current study. Firstly, miR-193a-3p level was detected in 125 cases of NSCLC with quantitative real-time PCR (qRT-PCR). Secondly, AEG-1 protein level was evaluated in 339 cases of lung cancers with immunohistochemistry. Finally, the relationship between miR-193a-3p and AEG-1 protein expression was verified in another group with 65 cases of NSCLC. The results showed that miR-193a-3p level was decreased in NSCLC tissues and significantly negatively related to tumor size (r = −0.277, P = 0.002), clinical TNM stage (r = −0.226, P = 0.011), lymph node metastasis (r = −0.186, P = 0.038), epidermal growth factor receptor (EGFR) protein level (r = −0.272, P = 0.041). On the contrary, AEG-1 protein expression was up-regulated in NSCLC and positively relative to tumor size (r = 0.240, P  0.001), TNM stages (r = 0.164, P = 0.002) and lymph node metastasis (r = 0.232, P  0.001) in NSCLC patients. In addition, miR-193a-3p was found to be inversely associated with AEG-1 protein expression in the third cohort (r = −0.564, P  0.001). In conclusion, miR-193a-3p and AEG-1 might be responsible for the carcinogenesis and aggressiveness of NSCLC. AEG-1 has the potential to be one of the targeted genes of miR-193a-3p. However, future in vitro and in vivo experiments are needed to verify this hypothesis.
机译：MiR-193A-3P和星形胶质细胞升高的基因-1（AEG-1）的异常表达已被揭示与各种癌症的肿瘤发生有关，包括非小细胞肺癌（NSCLC）。然而，未探讨MIR-193A-3P的重要性及其与NSCLC中AEG-1的相关性。本研究的目的是评估miR-193a-3p和aeg-1之间的关联及其与NSCLC患者临床病理特征的关系。通过在线在硅预测中，在miR-193a-3p和aeg-1的3'-wonsterlated区域之间发现互补序列。在目前的研究中应用了三个独立的队列。首先，在NSCLC的125例具有定量实时PCR（QRT-PCR）中检测miR-193a-3p水平。其次，在339例具有免疫组化的肺癌病例中评价AEG-1蛋白质水平。最后，在另一组中验证了MiR-193A-3P和AEG-1蛋白表达的关系，其中NSCLC 65例。结果表明，与肿瘤大小（R = -0.277，P = 0.002），临床TNM阶段（r = -0.226，p = 0.011），淋巴结转移明显呈肿瘤大小（r = -0.277，p = 0.011），淋巴结转移显着呈呈显着呈负相关（r = -0.277，p = 0.002）。 （r = -0.186，p = 0.038），表皮生长因子受体（EGFR）蛋白质水平（r = -0.272，p = 0.041）。相反，AEG-1蛋白表达在NSCLC中升高，相对于肿瘤大小（r = 0.240，p <0.001），TNM阶段（r = 0.164，p = 0.002）和淋巴结转移（r = 0.232） ，P <0.001）在NSCLC患者中。此外，发现miR-193a-3p与第三坐标中的AEG-1蛋白表达相反（R = -0.564，P <0.001）。总之，MiR-193A-3P和AEG-1可能对NSCLC的致癌和侵略性负责。 AEG-1具有潜在的MIR-193A-3P的靶向基因之一。然而，需要在体外​​和体内实验中进行未来进行验证这一假设。

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