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首页> 外文期刊>Cancer Management and Research >Serum Adipokines as Predictors for the Outcome of Prostate Biopsies at Early Stage Prostate Cancer Diagnosis
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Serum Adipokines as Predictors for the Outcome of Prostate Biopsies at Early Stage Prostate Cancer Diagnosis

机译：血清Adipokines作为前列腺前列腺癌诊断前列腺活组织检查结果的预测因子

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Purpose: Elevated adipokines in patients with obesity and metabolic syndrome have been linked to increased risk of prostate cancer (PCa). The association between select serum adipokines and the outcome of prostate biopsies alone and in combination with clinical parameters at different early stages of PCa was investigated. Patients and methods: Clinical data and serum adipokines were retrieved from three retrospective cohorts representing men at different points in PCa detection: 1. Subjects with no prior biopsies (n=1061), 2. subjects with a prior negative biopsy (REDUCE trial, control arm) (n=1209), 3. subjects with low-risk PCa on active surveillance (AS) (n=154). Adipokines were chosen based on an unpublished pilot study and included: Resistin, Tumor Necrosis Factor-α, Interleukin-6, Monocyte Chemoattractant Protein-1, Hepatocyte Growth Factor, and Nerve Growth Factor. The primary outcome was the absence of PCa on biopsy and the secondary outcome was diagnosis of low-risk PCa fitting the criteria for continuing AS. Logistic regression analysis was used to assess the association of adipokines and negative and/or low-risk PCa at prostate biopsy. Results: In men with no prior prostate biopsy or with prior negative biopsy, adipokines were not predictors of prostate biopsy outcomes on multivariable regression analysis controlling for known clinical variables. In the AS cohort, MCP-1 and Resistin were significant predictors of biopsy outcome on multivariable analysis (OR 0.20, 95% CI: 0.05–0.85, p= 0.03 & OR 0.30, 95% CI: 0.10 ?0.86, p= 0.03). Conclusion: Our findings do not support a strong role for adipokines for predicting the outcome of prostate biopsies at any early stage in PCa diagnosis.
机译：目的：肥胖症患者和代谢综合征患者的升高adipokines已与前列腺癌（PCA）的风险增加有关。研究了单独选择血清adipokines和前列腺活组织检查结果的结合和与PCA不同早期阶段的临床参数组合的关联。患者和方法：从三个回顾性队列中检索临床资料和血清adipokines，代表PCA检测不同点的男性：1。没有现有活检的受试者（n = 1061），2.受试者具有现有负面活组织检查的受试者（减少试验，控制，控制ARM）（n = 1209），3.主动监测（AS）上具有低风险PCA的受试者（AS）（n = 154）。基于未发表的试验研究选择adipokines，包括：抵抗素，肿瘤坏死因子-α，白细胞介素-6，单核细胞化学蛋白-1，肝细胞生长因子和神经生长因子。主要结果是缺乏PCA活检，二次结果是诊断低风险PCA拟合持续的标准。逻辑回归分析用于评估前列腺活组织检查的脂地电压和阴性和/或低风险PCA的关联。结果：在没有现有前列腺活检或具有前后活检的男性中，adipokines不是前列腺活检结果的预测因子对临床变量控制的多变量回归分析。在COHORT中，MCP-1和抵抗蛋白是多变量分析的活组织检查结果的显着预测因子（或0.20,95％CI：0.05-0.85，P = 0.03＆或0.30,95％CI：0.10？0.86，P = 0.03） 。结论：我们的研究结果不支持adipokines的强大作用，以预测PCA诊断早期前期前列腺活检的结果。

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