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首页> 外文期刊>Cancer Management and Research >The Significance of Adjuvant Therapy for Extrahepatic Cholangiocarcinoma After Surgery
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The Significance of Adjuvant Therapy for Extrahepatic Cholangiocarcinoma After Surgery

机译：佐剂治疗手术后辅助治疗的重要性胆管癌

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Extrahepatic cholangiocarcinoma (EHCC) is a rare malignant tumor, and current treatment methods are also relatively limited. Radical surgery is the only potentially curative method for the long survival time. However, despite undergoing radical resection, prognosis remained poor due to the high recurrence rate and distant metastasis. Therefore, adjuvant chemotherapy and radiotherapy should be offered to patients who have undergone surgery. Unfortunately, the low incidence of this disease has resulted in a lack of high-level evidence to confirm the importance of adjuvant chemotherapy or radiotherapy. At present, it is still controversial whether adjuvant therapy can prolong the survival of patients after operation, especially patients with negative margins or lymph nodes. Furthermore, standard regimens of adjuvant have not been identified. This review summarizes the currently available evidence of the effect of adjuvant therapy in the management of EHCC. Ultimately, we concluded that adjuvant therapy may improve survival in high-risk (positive margin or lymph node or advanced stage) patients and adjuvant concurrent chemoradiotherapy followed by chemotherapy may be the optimum selection for them. This needs to be verified by randomized prospective clinical trials.
机译：脱悬浮性胆管癌（EHCC）是一种罕见的恶性肿瘤，目前的处理方法也相对有限。自由基手术是长期生存时间的唯一潜在的治疗方法。然而，尽管发生了激进切除，但由于高复发率和远处转移，预后仍然差。因此，应向经历手术的患者提供佐剂化疗和放疗。不幸的是，这种疾病的低发病率导致缺乏高级别的证据来证实佐剂化疗或放射疗法的重要性。目前，辅助治疗是否可以延长患者的术后患者的存活，尤其是患有负余量或淋巴结的患者仍然存在争议。此外，尚未确定佐剂的标准方案。本综述总结了当前可用的辅助治疗在EHCC管理中效果的证据。最终，我们得出结论，佐剂治疗可以改善高风险（阳性边缘或淋巴结或晚期）患者的存活，以及佐剂同时进行化疗，然后进行化疗，可能是它们的最佳选择。这需要通过随机性前瞻性临床试验来验证。

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