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首页> 外文期刊>Cancer Management and Research >Increased Stromal Infiltrating Lymphocytes are Associated with Circulating Tumor Cells and Metastatic Relapse in Breast Cancer Patients After Neoadjuvant Chemotherapy
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Increased Stromal Infiltrating Lymphocytes are Associated with Circulating Tumor Cells and Metastatic Relapse in Breast Cancer Patients After Neoadjuvant Chemotherapy

机译：随着Neoadjuvant化疗后，随着乳腺癌患者的循环肿瘤细胞和乳腺癌患者的转移复发，增加的基质渗透淋巴细胞和乳腺癌患者

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Background: Circulating tumor cells (CTCs) intravasate into the bloodstream throughout early cancer stages, promoting metastasis. The tumor microenvironment plays a crucial role in disease progression and outcome. The aim of this prospective study was to investigate the associations of intratumoral and stromal tumor-infiltrating lymphocytes (TILs) with CTCs among patients receiving neoadjuvant chemotherapy (NAC). Methods: We analyzed CTCs in 30 patients with primary breast cancer before and after NAC. The numbers of intratumoral TILs (iTILs) and stromal TILs (sTILs) from pre-NAC formalin-fixed paraffin-embedded core biopsies and post-NAC surgical samples were analyzed. The associations of TILs with pathologic complete response (pCR) and outcome were also evaluated. Results: Of the 30 patients, pCR was achieved in nine (30.0%) patients. A total of 25 (83.3%) patients were CTC-positive before NAC, and eight (26.7%) patients were CTC-positive after NAC. Neither CTC detection before NAC nor CTC after NAC was predictive of pCR. Nevertheless, the presence of CTCs after NAC was significantly associated with early metastatic relapse ( P = 0.049) and worse disease-free survival ( P = 0.009). After NAC, total sTILs, CD4sup+/sup T cells, and CD8sup+/sup T cells were significantly correlated with CTC detection. Increased infiltration of sTILs and CD4sup+/sup T cells was also an unfavorable prognostic factor as measured by the rate of metastatic relapse. Conclusion: Detection of CTCs after NAC was positively associated with the metastatic relapse of breast cancer patients. Increased infiltration of sTILs after NAC was correlated with CTCs and was found to be an unfavorable prognostic factor.
机译：背景：循环肿瘤细胞（CTCs）在早期癌症阶段内血液流入血液，促进转移。肿瘤微环境在疾病进展和结果中起着至关重要的作用。该前瞻性研究的目的是探讨肿瘤和基质肿瘤浸润淋巴细胞（TILS）与CTCS接受Neoadjuvant化疗（NAC）的患者的关联。方法：在NAC之前和之后，我们分析了30名原发性乳腺癌患者的CTC。分析了来自NAC福尔马林固定的石蜡嵌入核心活组织检查和NAC后手术样品的肿瘤内直径（ITIL）和基质TIL（STILS）的数量。还评估了TILs与病理完全反应（PCR）和结果的关联。结果：30例患者，PCR在九（30.0％）患者中实现。 NAC之前，共有25例（83.3％）患者CTC阳性，NAC后八（26.7％）患者是CTC阳性。 NAC后NAC和CTC之前的CTC检测均未预测PCR。然而，NAC后CTCs的存在与早期转移复发显着相关（p = 0.049），并且无病的存活率更差（p = 0.009）。在NAC，总STILS，CD4 + T细胞和CD8 + T细胞与CTC检测显着相关。随着通过转移复发速率测量的，STILs和CD4 + T细胞的渗透增加也是一种不利的预后因素。结论：NAC后CTCS检测与乳腺癌患者的转移复发呈正相关。在NAC与CTC相关后，STILs的渗透增加，发现是一种不利的预后因素。

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