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T-Regulatory Cells In Tumor Progression And Therapy

机译：肿瘤进展和治疗中的T-调节细胞

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Regulatory T cells (Tregs) are important members of the immune system regulating the host responses to infection and neoplasms. Tregs prevent autoimmune disorders by protecting the host-cells from an immune response, related to the peripheral tolerance. However, tumor cells use Tregs as a shield to protect themselves against anti-tumor immune response. Thus, Tregs are a hurdle in achieving the complete potential of anti-cancer therapies including immunotherapy. This has prompted the development of novel adjuvant therapies that obviate their negative effects thereby enhancing the therapeutic efficacy. Our earlier studies have shown the efficacy of the glycolytic inhibitor, 2-deoxy-D-glucose (2-DG) by reducing the induced Tregs pool and enhance immune stimulation as well as local tumor control. These findings have suggested its potential for enhancing the efficacy of immunotherapy, besides radiotherapy and chemotherapy. This review provides a brief account of the current status of Tregs as a component of the immune-biology of tumors and various preclinical and clinical strategies pursued to obviate the limitations imposed by them in achieving therapeutic efficacy.
机译：调节性T细胞（Tregs）是免疫系统的重要成员，其调节对感染和肿瘤的宿主反应。 Tregs通过保护与外周耐受相关的免疫应答保护宿主细胞来防止自身免疫障碍。然而，肿瘤细胞使用Tregs作为屏蔽以保护自己免受抗肿瘤免疫应答。因此，Tregs是实现包括免疫疗法的抗癌疗法的完全潜力的障碍。这促使开发新的佐剂疗法，从而提高治疗效果的负面影响。我们之前的研究表明，通过减少诱导的Tregs池并增强免疫刺激以及局部肿瘤对照来表明糖酵解抑制剂，2-脱氧-D-葡萄糖（2-DG）的疗效。除了放疗和化疗之外，这些研究结果表明它提高了免疫疗法疗效的可能性。本综述简要介绍了Tregs作为肿瘤免疫生物学的组成部分，以及各种临床前和临床策略，旨在消除它们在实现治疗疗效方面施加的限制。

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