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首页> 外文期刊>Cancer Management and Research >High Inflammatory Factor Grading Predicts Poor Disease-Free Survival in AJCC Stage I-II Hepatocellular Carcinoma Patients After R0 Resection
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High Inflammatory Factor Grading Predicts Poor Disease-Free Survival in AJCC Stage I-II Hepatocellular Carcinoma Patients After R0 Resection

机译：高炎症因子分级在R0切除后AJCC阶段I-II肝细胞癌患者的无疾病存活率预测

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Purpose: In this study, we established the inflammatory factor grade system (IFGs) based on the hepatocellular carcinoma (HCC) microenvironment to investigate the role of inflammatory factor grade (IFG) in predicting the prognosis of patients with American Joint Committee on Cancer (AJCC) stage I-II. Patients and methods: We enrolled 87 HCC patients with AJCC stage I-II who underwent R0 resection between 2000 and 2012 and had paraffin-embedded specimens. Immunohistochemistry (IHC) was performed to investigate the expression of 12 inflammatory factors and then to establish the IFGs (grade A or B) based on the IHC data. Subsequently, Kaplan-Meier and Cox univariate/multivariate survival analyses were performed to examine the potential prognostic significance. Results: Higher IFG (IFG-B) is significantly associated with greater tumor size (P=0.037), and IFG-B predicts a worse disease-free survival (DFS, P0.001). Moreover, a platelet count (PLT) ≤100×10sup9/sup/L, tumor size ≥5 cm, poor tumor differentiation, and IFG-B are independent risk factors for DFS. Conclusion: Overall, by establishing a grading system for the level of inflammatory factors in the HCC microenvironment, IFG-B can effectively predict poor DFS in AJCC stage I-II HCC patients after R0 resection.
机译：目的：在本研究中，我们建立了基于肝细胞癌（HCC）微环境的炎症因子级系统（IFGS），以研究炎症因子等级（IFG）的作用预测美国联合癌症患者的预后（AJCC ）第I-II阶段。患者和方法：我们注册了87名HCC患者，AJCC阶段I-II患者在2000年至2012年期间接受了R0切除，并具有石蜡嵌入式标本。进行免疫组织化学（IHC）以研究12个炎症因子的表达，然后根据IHC数据建立IFGS（级A或B）。随后，进行Kaplan-Meier和Cox单变量/多变量存活分析以检查潜在的预后意义。结果：较高的IFG（IFG-B）与肿瘤大小（P = 0.037）显着相关（P = 0.037），IFG-B预测更差的无病生存率（DFS，P <0.001）。此外，血小板计数（PLT）≤100×10 9 / l，肿瘤大小≥5cm，肿瘤分化不良，IFG-B是DFS的独立风险因素。结论：总体而言，通过建立HCC微环境中炎症因子水平的分级系统，IFG-B可以在R0切除后有效地预测AJCC阶段I-II HCC患者的差DFS。

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