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首页> 外文期刊>Cancer Management and Research >Metastasectomy Improves the Survival of Gastric Cancer Patients with Krukenberg Tumors: A Retrospective Analysis of 182 patients
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Metastasectomy Improves the Survival of Gastric Cancer Patients with Krukenberg Tumors: A Retrospective Analysis of 182 patients

机译：Metastasectomy改善了胃癌患者的Krukenberg肿瘤的存活：182例患者的回顾性分析

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Purpose: There is no consensus regarding whether metastasectomy in gastric cancer patients with Krukenberg tumors (KTs) is associated with survival benefits. The aim of this study was to evaluate the treatment of KTs of gastric origin in a large series of patients and to identify prognostic factors affecting survival. Patients and Methods: All patients who were diagnosed with gastric cancer and ovarian metastases in a single medical center between January 2006 and December 2016 were identified and included. The patients were divided into two groups according to treatment modality: a metastasectomy group and a nonmetastasectomy group. Clinicopathological features and overall survival (OS) were compared between the groups. Results: In total, 182 patients were identified; 94 patients presented with synchronous KTs, and 88 developed metachronous KTs during follow-up. OS was significantly longer in the metastasectomy group than in the nonmetastasectomy group among those with synchronous (14.0 months vs 8.0 months; p = 0.001) and metachronous (14 months vs 8 months; p = 0.018) KTs. Multivariate analysis indicated that metastasectomy (hazard ratio [HR] 0.537; 95% confidence interval [CI] 0.344–0.839; p = 0.006), ascites (HR 1.523; 95% CI 1.058–2.193; p = 0.024), linitis plastica (HR 1.995; 95% CI 1.115–3.571; p = 0.020), and systemic chemotherapy (HR 0.456; 95% CI 0.280–0.742; p = 0.002) were independent predictors of OS. Conclusion: Metastasectomy combined with systemic chemotherapy should be performed in gastric cancer patients with synchronous or metachronous KTs. Metastasectomy, systemic therapy, linitis plastica, and ascites are prognostic factors for OS. Further prospective randomized studies are needed.
机译：目的：胃癌患者是否患有Krukenberg肿瘤（KTS）的胃癌患者是否与生存益处有关的共识。本研究的目的是评估大量患者中胃源血管KTS的治疗，并鉴定影响存活的预后因素。患者和方法：确定并包括在2006年1月至2016年1月至2016年1月至2016年12月之间诊断患有胃癌和卵巢转移的患者。根据治疗方式分为两组，患者分为两组：一种雌乳切除术组和非口头切除术。在组之间比较临床病理特征和整体存活（OS）。结果：共有182名患者; 94名患者呈现同步KTS，随访期间88名开发的比赛。在转移术中的组切除术比在非男性切除术中具有同步（14.0个月Vs 8.0个月）的OS显着更长的组切除术群体较长较长多变量分析表明，转移术（危害比[HR] 0.537; 95％置信区间[CI] 0.344-0.839; P = 0.006），腹水（HR 1.523; 95％CI 1.058-2.193; P = 0.024），乳膜炎塑料植物（HR 1.995; 95％CI 1.115-3.571; P = 0.020），和全身化疗（HR 0.456; 95％CI 0.280-0.742; p = 0.002）是OS的独立预测因子。结论：胃癌患者的同步或比较KTS的胃癌患者均联合全身化疗组切除术。 Metastasectomy，全身治疗，乳腺炎塑料，和腹水是OS的预后因素。需要进一步的预期随机研究。

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