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首页> 外文期刊>Cancer Management and Research >Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage
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Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage

机译：子宫颈小细胞癌的预后因素及局部治疗方式：根据国际妇科和产科阶段联合会分析

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Purpose: Small-cell carcinoma of the cervix (SCCC) is a rare type of cervical cancer. This study aimed to investigate the clinicopathological characteristics and survival as well as the optimal local treatment modalities for SCCC. Patients and Methods: We retrospectively evaluated the data of patients diagnosed with SCCC between 1988 and 2015 in our institution – those included in the Surveillance, Epidemiology, and End Results (SEER) database and those in the Periodical Database. Kaplan–Meier method and Cox regression proportional hazard methods were used to evaluate overall survival (OS). A nomogram that could predict OS was constructed based on the Cox proportional hazard model. Results: In total, 695 patients were included in this study. The 5-year overall survival in FIGO stage I-IIA and IIB-IV patients was 45.7% and 14.4%, respectively ( P 0.01). Univariate and multivariate analyses showed that lymph node status ( P 0.01) and cancer-directed surgery ( P 0.01) were independent prognostic factors for FIGO I-IIA stage patients, and age ( P 0.05), tumor size ( P 0.01), chemotherapy ( P 0.01) and radiation ( P 0.01) were independent prognostic factors for FIGO stage IIB-IV patients. Conclusion: Better prognosis was associated with negative lymph node status, no lymphatic vasculature, surgery, and early-stage patients. Furthermore, our data showed that the prognosis and treatment pattern varied depending on the FIGO stage, and that optimal treatment modalities included radical surgery for early-stage SCCC and chemoradiotherapy for advanced-stage SCCC. It is helpful to assess the individual prognosis of SCCC patients and choose personalized treatment modalities.
机译：目的：子宫颈的小细胞癌（SCCC）是一种罕见的宫颈癌。本研究旨在调查临床病理特征和生存以及SCCC的最佳局部治疗方式。患者和方法：我们回顾性地评估了在我们机构的1988年和2015年间诊断SCCC的患者的数据 - 包括在监测，流行病学和最终结果（SEER）数据库和期刊数据库中的那些。 Kaplan-Meier方法和Cox回归比例危险方法用于评估整体存活（OS）。可以基于Cox比例危险模型构建了可以预测OS的铭文图。结果：总共包括695名患者。 Figo Stage I-IIA和IIB-IV患者的5年总生存率分别为45.7％和14.4％（P <0.01）。单变量和多变量分析显示淋巴结状态（P <0.01）和癌症手术（P <0.01）是FIGO I-IIA患者的独立预后因素，年龄（P <0.05），肿瘤大小（P <0.01） ），化疗（P <0.01）和辐射（P <0.01）是FOGO阶段IIB-IV患者的独立预后因素。结论：更好的预后与阴性淋巴结状态，无淋巴脉管系统，手术和早期患者有关。此外，我们的数据表明，预后和治疗模式根据FIGO阶段而变化，并且最佳治疗方式包括用于早期SCCC和晚期SCCC的早期SCCC和化学疗法的激进手术。评估SCCC患者的个性化预后并选择个性化治疗方式有助于。

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