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首页> 外文期刊>Canine Genetics and Epidemiology >Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance
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Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance

机译：IRISH Wolfhounds中心房颤动的血管纤维化谱系分析支持具有优势的遗传模式的高遗传性

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Background:Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices.Results:There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8?years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50-0.86). The pedigree was consistent with a dominant mode of inheritance.Conclusion:Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted.? The Author(s). 2019.
机译：背景：心房颤动（AF）是狗中最常见的心律失常。爱尔兰沃尔夫霍恩品种对AF的患病率很高，使其成为探讨这种疾病可能的遗传贡献的理想品种。本研究的目的是在北美爱尔兰狼群中使用来自2000和2019年之间的心脏筛查的表型数据进行遗传性分析，以确定与环境原因相比遗传归因于遗传学的大部分。第二个目的是确定遗传的疾病模式，以帮助预防和育种惯例。结果：有327名爱尔兰猎犬诊断为AF和136岁以上8岁以上没有AF的volfhounds。 IRISH Wolfhounds中AF的估计平均值（95％置信区间）可遗传性为0.69（0.50-0.86）。血统与主要的遗传模式一致。结论：本研究的结果表明对爱尔兰沃尔夫犬的AF的强烈遗传贡献，并暗示了识别造成致病性遗传突变的未来研究。？作者。 2019年。

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