• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Case Reports in Dermatological Medicine >Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy
【24h】

Perianal Basal Cell Carcinoma Successfully Managed with Excisional Biopsy

机译：肛周基础细胞癌成功与促进活检进行管理

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the United States and is often nonaggressive. Its location in the perianal region is very rare and it is estimated that only 0.08% of all BCCs occur in this region. Herein, we present a case of perianal basal cell carcinoma, nodular type. The diagnosis was made using excisional biopsy of a skin lesion. Immunohistochemical staining confirmed the diagnosis: it showed diffuse and strong positivity for smooth muscle actin (SMA) and monoclonal antibody BER-Ep4 and was negative for carcinoembryonic antigen (CEA), pancytokeratin (AE1/AE3), and epithelial membrane antigen (EMA). The treatment of choice has traditionally been local excision to clear margins but the newest guidelines recommend Mohs Micrographic surgery (MMS) or standard 4mm surgical margins for this high-risk BCC. Our patient was successfully treated using excisional biopsy without recurrence. In select patients with lesions smaller than 1cm, excisional biopsy may be sufficient to treat the disease and may be better tolerated than MMS and wider surgical margins. Literature review suggests a predisposition for perianal BCC in individuals susceptible to cutaneous malignancies. Therefore, any history of cutaneous malignancy should further prompt clinicians to examine nonsun exposed areas on full body skin exams.
机译：基底细胞癌（BCC）是美国最常见的皮肤病恶性，并且通常是不良的。它位于围裙地区的位置非常罕见，估计该地区仅发生了0.08％的BCC。在此，我们提出了肛周基础细胞癌，结节型。使用皮肤病变的切除活组织检查进行诊断。免疫组织化学染色证实了诊断：它显示出平滑肌肌动蛋白（SMA）和单克隆抗体BES-EP4的弥漫性和强大的阳性，并且对于癌胚胎抗原（CEA），韧皮肽（AE1 / AE3）和上皮膜抗原（EMA）是阴性的。选择的待遇传统上是局部切除清除边缘，但最新的指导推荐Mohs显微手术（MMS）或标准的4mm手术边距，用于这种高风险的BCC。我们的患者在没有复发的情况下成功使用切除活检进行治疗。在选择小于1cm的病变的患者中，可以足以治疗疾病并且可以比MMS和更宽的手术边缘更好地耐受性。文献综述表明，肛门BCC在易受皮肤恶性肿瘤的肛门菌中易感性。因此，任何皮肤恶性历史都应进一步提示临床医生，以检查全身皮肤检查的非季暴露区域。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号