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首页> 外文期刊>Case Reports in Pathology >Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern
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Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern

机译：纤维细胞外球体在内镜超声引导的胰腺细针抽吸与齐叶胰内分泌肿瘤相关，具有独特的鹅卵石路面生长模式

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Pancreatic neuroendocrine neoplasms (PanNENs) are uncommon tumors. Fine needle aspiration (FNA) samples from PanNENs are typically of high cellularity and lack necrosis. In cytology slides from these tumors, dyscohesive cells are usually reported with variably round to oval to plasmacytoid forms exhibiting coarsely granular chromatin and showing immunoreactivity for synaptophysin. We present an unusual, and to our knowledge not previously described, example of an FNA of a PanNEN with large extracellular fibrous spheroids containing intrinsic fibroblasts and rimmed by small to intermediate sized neoplastic epithelial cells with high nuclear cytoplasmic ratios. The cytomorphology of the PanNEN in this case was in some ways reminiscent of that expected in adenoid cystic carcinomas of the salivary glands that most often contain large extracellular globules of basement membrane material and a somewhat biphasic population of lesional cells. The cytomorphology in this case was found to correlate well with the resection specimen histomorphology of an exaggerated gyriform pattern of growth resulting in a unique cobblestone-pavement like microscopic appearance. Knowledge of this potential cytomorphology will aid the cytology community through recognition and reporting of this previously undescribed pattern in an uncommon disease.
机译：胰腺神经内分泌肿瘤（Pannens）是罕见的肿瘤。来自Pananens的细针抽吸（FNA）样品通常具有高细胞性和缺乏坏死。在细胞学中，来自这些肿瘤的载玻片，通常以可变的圆形循环向椭圆形表现出粗糙颗粒染色质的卵形圆形细胞，并显示突触蛋白的免疫反应性。我们提出了一种不寻常的，并向我们之前未描述的知识，具有含有内在成纤维细胞的大型细胞外纤维状球体的Pannen的FNA的实例，并通过小于中等大小的肿瘤上皮细胞，具有高核细胞质比例。在这种情况下，Pannen的细胞形态是在某种程度上使得在唾液腺的腺样囊性癌中的某种程度上是最常含有大型膜材料的大型细胞外球状和稍微的损伤细胞群体的唾液腺。发现这种情况下的细胞形态与夸张的曲线的切除标本组织形态学的夸张的曲面的生长模式相关，导致独特的鹅卵石路面，如显微镜外观。对这种潜在的细胞形态的了解将通过在罕见疾病中识别和报告此前未描述的模式来帮助细胞学群体。

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