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首页> 外文期刊>Ceylon Medical Journal >Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka
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Association of Serum Uric acid and Gamma-glutamyltransferase with Obesity Related Metabolic Derangements in a Cohort of Children with Obesity in Sri Lanka

机译：血清尿酸和γ-谷氨酰胺转移酶与肥胖症患者肥胖症中肥胖症患者肥胖症中的肥胖症相关的代谢紊乱

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Introduction: Gamma-glutamyltransferase (GGT) and serum uric acid (UA) are known to be associated with cardiovascular disease in obese children.?Objectives: To determine the association of serum UA and GGT with components of metabolic syndrome (MetS) in a group of obese children and determine the validity of UA and GGT in predicting MetS.?Methods: Cross sectional analytical study was conducted among 205, 5-15 year old obese children. After a 12- hour overnight fast, blood was drawn for glucose, lipid profile, alanine aminotransferase (ALT), aspartate aminotransferase (AST), insulin, UA and GGT. Oral glucose tolerance test (OGTT) was done with 2 hour plasma glucose. Height, weight, waist circumference,blood pressure and fat mass were measured. USS of abdomen was performed to assess hepatic steatosis.?Results: Chi square test showed statistically significant associations between GGT and UA with triglyceride, insulin resistance (HOMA-IR), AST, ALT, AST/ALT ratio and fatty liver. Additionally UA showed a significant association with the OGTT. With existing cut offs (GGT >30 U/L and UA >330 μmol/L) the sensitivity and specificity of GGT in predicting MetS was 19% (95% CI, 13.63-24.37) and 88.4% (95% CI, 84.02-92.78) respectively while for UA was 28.6% (95% CI, 22.42-34.78) and 80.2% (95% CI, 74.75-85.65) respectively. A new cut off value of 19.5 U/L (sensitivity 56% and specificity 55%) for GGT and 275.5 μmol/L (sensitivity 61% and specificity 54%) for UA predicted MetS with greater accuracy.?Conclusion: GGT and UA are strongly associated with metabolic derangements and these biomarkers are rather weak in predicting MetS.
机译：介绍：已知γ-谷氨酰胺转移酶（GGT）和血清尿酸（UA）与肥胖儿童的心血管疾病有关。：确定血清UA和GGT与组组分中的组分（METS）的关联肥胖儿童确定UA和GGT在预测Mets中的有效性.?Methods：横断面分析研究是在205，5-15岁的肥胖儿童中进行的。在快速12小时后，为葡萄糖，脂质型，丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），胰岛素，UA和GGT进行血液。用2小时血浆葡萄糖进行口服葡萄糖耐量试验（OGTT）。测量高度，重量，腰围，血压和脂肪质量。进行了腹部的胃脂肪化。治疗肝脏脂肪变性。奇方检验显示GGT和UA与甘油三酯，胰岛素抵抗（HOMA-IR），AST，AST，AST，AST / ALT比和脂肪肝之间的统计显着的关联。另外，UA显示出与OGTT有很大的关联。具有现有切断（GGT> 30 U / L和UA>330μmol/ L）GGT在预测MET中的敏感性和特异性为19％（95％CI，13.63-24.37）和88.4％（95％CI，84.02- 92.78）分别为UA为28.6％（95％CI，22.42-34.78）和80.2％（95％CI，74.75-85.65）。用于GGT的GGT和275.5μmol/ L（灵敏度61％和特异性55％）的新切断值为UA预测的UA预测的275.5μmol/ L（灵敏度61％和特异性54％），具有更大的准确性。结论：GGT和UA是与代谢紊乱强烈相关，这些生物标志物在预测MET中相当弱。

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