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首页> 外文期刊>Chemical Science International Journal >Anti Stress Activity of Phytoecdysteroids Isolated from Aerial Part of Silene claviformis
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Anti Stress Activity of Phytoecdysteroids Isolated from Aerial Part of Silene claviformis

机译：从硅烯克拉维斯的空中部分分离的植物雌谱的抗应激活性

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Aims: The aim of present study was to isolate the phytoedysteroids from aerial part of Sileneclaviformis (Caryophyllaceae) and investigate their biological activity.Place and Duration of Study: The investigation were carried out during 2019 and 2020 atlaboratory of the chemistry of glycosides and department of the pharmacological and toxicology ofInstitute of the Chemistry of Plant Substances AS RUz, Tashkent, Uzbekistan.Methodology: The phytoecdysteroids were isolated from aerial part of Silene claviformis usingchromatographic methods. Thin-layer chromatography made on Silufol UV-254 and Merck plates,Fluka Analytical Germany, by spraying with alcohol solution of vanillin and heating for 1-2 minutesfor 90-100 0 , UV lamp light at 254 nm and 365 nm. Their structures were confirmed by NMR and IRspectroscopy. Sum of phytoecdysteroids was administered at a dose of 10 mg/kg orally. The dataobtained during the experiments were processed and analyzed by the method of variation statisticsusing the Student t-criterion.Results: Silene claviformis contains 2-deoxyecdysterone (1), polypodine B (2), 20-hydroxyecdysone (3), ecdysterone-20,22-acetalisovaleric aldehyde(4),integristeron A (5),cyasterone(6), ecdysterone-20,22-acetalisovalerian (7), 2-deoxy-α-ecdysone(8). The compounds2 and 6 are reported for the first time from this genus. The biological activity (stress-protectiveeffect) of the mentioned phytoecdysteroids studied for the first time. These compounds were testedon male mice for their biological activities and results showed that, the adrenal gland massincreased in relation to the adrenal gland mass of intact animals by 42.6%, they showed asignificant decrease in the content of ascorbic acid and cholesterol by 56.5 and 49.1%, respectively.A significant decrease in glycogen content (by 30.1%) and a noticeable activation of lipidperoxidation processes were noted in the liver, as indicated by an increase of 69.2% in the contentof malondialdehyde in the organ.Conclusion: This is the first study reporting an orally biological investigation for Silene claviformis.The sum of phytoecdysteroids showed potent stress-protective activity. The stress-protective effectof phytoecdysteroids was more pronounced in compared the eleutherococcus extract.
机译：目的研究：目前的研究目的是将植物部分的植物部分分离出来自Sileneclavifordis（蛛网曲霉）的空中部分并研究其生物学活性.Place和研究持续时间：2019年进行调查和2020年的糖苷化学和部门的化学化学。植物物质化学化学和毒理学作为Ruz，Tashkent，乌兹别克斯坦的药理和毒理学。方法：植物中的植物克拉维肌的平等分离使用糠瘤方法。薄层色谱法制造的Silufol UV-254和Merck板，Fluka分析德国，通过用Vanillin的醇溶液喷洒，加热1-2分钟，以90-100 0，UV灯光，在254nm和365nm。通过NMR和IRSpectroscopy证实了它们的结构。口服10mg / kg的剂量给予植物谱和植物的总和。通过测定学生T标准的变异统计学方法处理和分析实验期间的数据细胞。结果：溶解剂：硅烯克拉维菊酯含有2-exoxyecdysterone（1），聚蛋白质B（2），20-羟基迪晶酮（3），EcdeStone-20， 22-乙醛醛醛（4），二（5），柳酮（6），EcdeSterone-20,22-乙醛甲醛（7），2-脱氧-α-蜕膜（8）。从该属中首次报告化合物2和6。提到的植物中提到的生物活性（应激保护率）第一次研究。这些化合物是睾丸雄性小鼠的生物活性和结果表明，肾上腺按原样与完整动物的肾上腺质量相对于42.6％，它们表现出抗坏血酸和胆固醇含量的显着降低56.5％和49.1％分别在肝脏中注意到糖原含量的显着降低和脂质氧化方法的明显激活，如机组人酰亚胺酰亚胺含量的69.2％增加。结论：这是第一项研究报告对硅霉素的口头生物学研究。植物植物植物的总和显示出有效的应力保护活性。在与Eleutherococcus提取物相比，植物雌甾醇的压力保护作用更加明显。

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