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Development of Microfluidic Components for Micro Total Analysis Systems

机译:微流体组分的微流体分析系统的开发

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Microfluidic device is capable of reducing amount of sample consumption, shortening the analysis time, and miniaturizing instruments. Many applications of microfluidic devices have been developed not only in chemical analysis but also in medical diagnosis, and the food and agricultural industries. Electrophoresis or chromatography in a microfluidic device has improved the speed, reproducibility and separation resolution. Some of them have been integrated with complex experimental functionality on a small substrate, of which concept is known as micro total analysis systems. To build up a system, microfluidic components that carry out an experimental functionality in a microfluidic channel and novel technology to support the developments of microfluidic components are indispensable. In this review, three-dimensional (3D) fabrication by thiol-ene quick reaction, sample injection with an inkjet ejector, and molecular detection based on electroosmosis are focused briefly. The 3D fabrication realizes to make various 3D microstructures that conventional fabrication method cannot make without specific equipment. The sample injection by using inkjet technology can apply tiny amount of sample solution into multiple microfluidic channel on some precise spots, which leads to rapid analysis with high accuracy. The electroosmosis-based molecular detection indicates a possibility to develop a new portable device without any peripherals for detection or pretreatment for specimen labeling. Abstract Microfluidic device is capable of reducing amount of sample consumption, shortening the analysis time, and miniaturizing instruments. Many applications of microfluidic devices have been developed not only in chemical analysis but also in medical diagnosis, and the food and agricultural industries. Electrophoresis or chromatography in a microfluidic device has improved the speed, reproducibility and separation resolution. Some of them have been integrated with complex experimental functionality on a small substrate, of which concept is known as micro total analysis systems. To build up a system, microfluidic components that carry out an experimental functionality in a microfluidic channel and novel technology to support the developments of microfluidic components are indispensable. In this review, three-dimensional (3D) fabrication by thiol-ene quick reaction, sample injection with an inkjet ejector, and molecular detection based on electroosmosis are focused briefly. The 3D fabrication realizes to make various 3D microstructures that conventional fabrication method cannot make without specific equipment. The sample injection by using inkjet technology can apply tiny amount of sample solution into multiple microfluidic channel on some precise spots, which leads to rapid analysis with high accuracy. The electroosmosis-based molecular detection indicates a possibility to develop a new portable device without any peripherals for detection or pretreatment for specimen labeling.
机译:微流体装置能够降低样品消耗量,缩短分析时间和小型化仪器。微流体装置的许多应用不仅在化学分析中开发,也开发了医学诊断和食品和农业产业。微流体装置中的电泳或色谱法提高了速度,再现性和分离分辨率。其中一些已经在小型基板上与复杂的实验功能集成,其中概念被称为微量分析系统。为了建立系统,在微流体通道和新技术中进行实验功能的微流体组分是必不可少的。在该评价中,三维(3D)通过硫醇-NEE快速反应的制造,用喷墨喷射器的样品喷射,以及基于电渗的分子检测是短暂的。 3D制造实现了使传统制造方法不能在没有特定设备的情况下制造的各种3D微结构。使用喷墨技术的样品注入可以将微量样品溶液施加到多个微流体通道上的一些精确斑点,这导致高精度的快速分析。基于电渗的分子检测表示可能在没有任何外围设备的情况下开发新的便携式设备,用于检测或预处理样品标记。摘要微流体装置能够降低样品消耗量,缩短分析时间和小型化仪器。微流体装置的许多应用不仅在化学分析中开发,也开发了医学诊断和食品和农业产业。微流体装置中的电泳或色谱法提高了速度,再现性和分离分辨率。其中一些已经在小型基板上与复杂的实验功能集成,其中概念被称为微量分析系统。为了建立系统,在微流体通道和新技术中进行实验功能的微流体组分是必不可少的。在该评价中,三维(3D)通过硫醇-NEE快速反应的制造,用喷墨喷射器的样品喷射,以及基于电渗的分子检测是短暂的。 3D制造实现了使传统制造方法不能在没有特定设备的情况下制造的各种3D微结构。使用喷墨技术的样品注入可以将微量样品溶液施加到多个微流体通道上的一些精确斑点,这导致高精度的快速分析。基于电渗的分子检测表示可能在没有任何外围设备的情况下开发新的便携式设备,用于检测或预处理样品标记。

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