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首页> 外文期刊>Bangladesh Journal of Medical Science >Serum immunoglobulins and anti-pneumococcal antibody levels in patients with bronchiectasis of unknown aetiology
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Serum immunoglobulins and anti-pneumococcal antibody levels in patients with bronchiectasis of unknown aetiology

机译：血清免疫球蛋白和抗肺炎球菌抗体水平患者未知病毒学的支气管扩张

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Background: Bronchiectasis is a chronic condition which can result in significant physical and social morbidity. The exact prevalence in Malaysia is unknown although several studies have shown a higher prevalence in the Asian population. Several causative factors have been identified but there are many patients with unknown aetiologies. This study looks into the level of serum immunoglobulins and antipenumococcal antibody in bronchiectasis patients where they were not part of prior routine investigations. Methodology: Four hundred fifteen bronchiectasis patients were screened and 26 patients who fulfilled the inclusion and exclusion criteria were enrolled for this study. The serum immunoglobulins (IgG, IgA and IgM) concentrations were measured using nephelometry and interpreted according to age-matched reference range. The integrity of antibody production against specific antibody to capsular polysaccharides of Streptococcus pneumoniae were assessed using ELISA method and the level of ≥ 10mg/L is considered as reactive. Results : The twenty six bronchiectasis patients have the mean age of 62 years and a predilection of female gender. Majority of patients presented with typical bronchiectasis symptoms which were further supported by radiological findings. One of 26 patients (4%) had low total serum IgG level. The vaccinated group has higher anti-pneumococcal capsular polysaccharide antibody level (median: 224.2 mg/L) compared to the unvaccinated group (median: 100.4 mg/L). However there is no statistical difference between the anti-PCP levels of both groups (p 0.05). All of the selected patients had reactive specific antibody to capsular polysaccharides of Streptococcus pneumoniae regardless of the vaccination status, which may reflect the natural acquisition of anti-pneumococcal immunity. Conclusion: Although immunoglobulin deficiency is an uncommon aetiological cause of bronchiectasis, the immunoglobulin parameters can be helpful in selecting patients who should receive the appropriate treatment of immunoglobulin therapy for the prevention of subsequent complications and better quality of life.
机译：背景：支气管扩张是一种慢性病，可能导致重大的身体和社会发病率。马来西亚的确切普遍性是未知的，尽管有几项研究表明亚洲人口普遍存在较高。已经确定了几种致病因素，但有许多患者患有未知的疾病。本研究研究了支气管扩张患者的血清免疫球蛋白和抗胰管癌抗体的水平，在那里他们不是先前常规研究的一部分。方法论：筛查四百叶绿交患者，均征收含有夹杂物和排斥标准的26名患者。使用Nephelomerry测量血清免疫球蛋白（IgG，IgA和IgM）浓度，并根据年龄匹配的参考范围解释。使用ELISA法评估抗体产生对肺炎链球菌肺炎链球菌囊多糖的抗体产生的完整性，≥10mg/ L的水平被认为是反应性的。结果：二十六个支气管扩张患者的平均年龄为62岁，女性性别的预防。大多数患者呈现出典型的支气管扩张症状，进一步通过放射发现得到了进一步支持。 26名患者中的一个（4％）总血清IgG水平较低。与未接种催乳群（中位数：100.4mg / L）相比，疫苗接种基团具有更高的抗肺炎球菌荚膜多糖抗体抗体（中位数：224.2mg / L）。然而，两组抗PCP水平之间没有统计学差异（P> 0.05）。无论疫苗接种状态如何，所有选定的患者都对链球菌肺炎链球菌囊多糖具有反应性的特异性抗体，这可能反映了抗肺炎球菌免疫的自然采集。结论：虽然免疫球蛋白缺乏是一种罕见的支气管切除的病因，但免疫球蛋白参数可以有助于选择应接受免疫球蛋白治疗的患者，以预防随后的并发症和更好的生活质量。

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