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首页> 外文期刊>Ciência & Saúde Coletiva >Characterization of Enzymatic profiles of Aedes aegypti strains from the State of Rio Grande do Norte, Brazil
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Characterization of Enzymatic profiles of Aedes aegypti strains from the State of Rio Grande do Norte, Brazil

机译：从Rio Grande Do Norte，巴西北京北京北京北京AEGYPTI菌株的酶促谱

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摘要

This study was conducted in four strains of Aedes aegypti mosquitoes to evaluate the enzymatic activity profiles in the city of Mossor?3, Rio Grande do Norte, and correlate them with biochemical mechanisms of resistance to insecticides. Mosquitos were used to quantify the following detoxification enzymes: Mixed-Function Oxidase (MFO), PNPA-esterase (PNPA-EST), and Acetylcholinesterase (AChE). The profiles were compared statistically with profiles from the Rockefeller strain, through the Kruskal-Wallis test and Dunn's multiple comparisons (p < 0.05). The 99 percentile of the values of enzyme activity from the reference strain was calculated for each enzyme, and the percentage of individuals above the 99 percentile was quantified. The enzyme activities were classified as a??Unchangeda?? (< 15%), a??Identified changea?? (> 15% and < 50%), and a??Substantially changeda?? (> 50%). The statistical analysis revealed significant differences in the MFO and AChE profiles, which are fundamental in the determination of profiles of resistance to insecticides. Three populations were classified as a??Substantially changeda?? for MFO. The altered enzymatic activity showed that the changes could have an important role in exposing resistance to insecticides.
机译：本研究进行了四种AEGYPTI蚊子的菌株，以评估矿物城市中的酶活性曲线？3，RIO Grande Do Norte，并将它们与抗杀虫剂的生化机制相关联。蚊虫用于量化以下解毒酶：混合功能氧化酶（MFO），PNPA-酯酶（PNPA-EST）和乙酰胆碱酯酶（ACHE）。通过Kruskal-Wallis试验和DUNN的多重比较，统计地将曲线与梯子菌株的曲线进行统计比较。针对每种酶计算来自参考菌株的酶活性的99百分位数，量化了99％以上的个体的百分比。酶活性被归类为一个答案的不变？ （<15％），一个??鉴定的长期？ （> 15％和<50％），一个??基本上换成了？ （> 50％）。统计学分析显示了MFO和ACHE曲线的显着差异，这是抗杀虫剂抗性谱的基础。三个人群被归类为一个???基本上换句道？对于MFO。改变的酶活性表明，变化可在暴露对杀虫剂的耐受性方面具有重要作用。

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