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首页> 外文期刊>Circulation journal >Impact of Chronic Kidney Disease on Left Main Coronary Artery Disease and Prognosis in Japanese Patients
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Impact of Chronic Kidney Disease on Left Main Coronary Artery Disease and Prognosis in Japanese Patients

机译：慢性肾病对日本患者左主要冠状动脉疾病及预后的影响

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Background: Renal insufficiency plays a critical role in the pathogenesis of ischemic heart disease. The aim of the present study was to investigate the prevalence of renal dysfunction and its impact on prognosis in patients with left main coronary artery disease (LMCAD) and stable angina pectoris. Methods and Results: A total of 626 consecutive patients with significant coronary artery stenosis were enrolled. Renal insufficiency was graded using estimated glomerular filtration rate (eGFR) before coronary angiography. Chronic kidney disease (CKD) was defined as eGFR –1·1.73m–2 and/or proteinuria. Patients with LMCAD (n=95) had a significantly higher prevalence of CKD than those without LMCAD (P=0.02). Multiple logistic regression analysis showed that CKD was independently associated with LMCAD (adjusted odds ratio, 1.74; 95% confidence interval [CI]: 1.09–2.76, P=0.01). A 1-year follow-up of patients with LMCAD showed that the cumulative incidence of major adverse cardiovascular events among patients with eGFR –1·1.73m–2 was higher than that among patients with eGFR ≥60ml·min–1·1.73m–2 (P=0.03). The hazard ratio for a cardiovascular event was 9.54 (95% CI: 3.15–28.89, P–1·1.73m–2 vs. patients without LMCAD and eGFR ≥60ml·min–1·1.73m–2. Conclusions: Renal insufficiency is a risk factor for LMCAD and predicts poor prognosis in Japanese patients. ( Circ J 2012; 76: 2266–2272)
机译：背景：肾功能不全在缺血性心脏病发病机制中发挥着关键作用。本研究的目的是探讨肾功能紊乱的患病率及其对左主冠状动脉疾病（LMCAD）和稳定的心绞痛患者预后的影响。方法和结果：共征收626例冠状动脉狭窄的626名患者。在冠状动脉血管造影之前，使用估计的肾小球过滤速率（EGFR）进行肾功能不全。慢性肾病（CKD）定义为EGFR -1 ·1.73m -2 和/或蛋白尿。 LMCAD患者（n = 95）的CKD患病率明显高于没有LMCAD的CKD（P = 0.02）。多重逻辑回归分析显示CKD与LMCAD独立相关（调整后的差距，1.74; 95％置信区间[CI]：1.09-2.76，P = 0.01）。 LMCAD患者的一年后续随访表明，EGFR -1·1.73M -2患者患者的主要不良心血管事件的累积发生率高于患者患者的患者EGFR≥60ml·min -1 ·1.73m -2 （p = 0.03）。心血管事件的危险比为9.54（95％CI：3.15-28.89，P-1 ·1.73M -2 与没有LMCAD的患者，EGFR≥60ml·min -1 ·1.73m -2 。结论：肾功能不全是LMCAD的危险因素，预测日本患者的预后差。（2012年CIRC; 76：2266-2272）

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