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首页> 外文期刊>Circulation journal >Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan　– A 10-Year Nationwide Population-Based Study –
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Hormone Therapy and Risk of Venous Thromboembolism Among Postmenopausal Women in Taiwan　– A 10-Year Nationwide Population-Based Study –

机译：台湾绝经后妇女的激素治疗与静脉血栓栓塞的风险 - 全国10年的人口研究 -

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Background: The incidence of venous thromboembolism (VTE) in Asians is lower than in Caucasians, but the risk of VTE associated with hormone therapy (HT) in Taiwanese postmenopausal women has not been determined. Methods?and?Results: From Taiwan’s National Health Insurance Research Database, we established matched cohorts (HT users and nonusers) of postmenopausal women aged ≥50 years between 1 January 1998 and 31 December 2008. We calculated the 2-year incidence of VTE in HT users and nonusers. HT users and nonusers were matched 1:1 based on propensity-score matching. Cox regression hazard model was used to identify risk factors of VTE. We initially identified 499,594 HT users and 424,963 nonusers. There were higher percentages of cancer and cardiovascular events among the HT nonusers. After matching, the VTE incidence was 4.4 vs. 2.6 per 10,000 patient-years (adjusted hazard ratio 1.796, 95% confidence interval 1.272–2.537) in HT users and nonusers, respectively. The Cox regression hazard model showed that HT use, older age, malignancy, heart failure, and recent major surgery were independent risk factors for VTE. Conclusions: Although the incidence of VTE was very low among this cohort of Taiwanese postmenopausal women, oral HT was still associated with an increased risk of VTE. Therefore, physicians should be aware of other potential VTE risk factors when prescribing oral HT to postmenopausal women. ( Circ J 2015; 79: 1107–1114)
机译：背景：亚洲静脉血栓栓塞（VTE）的发病率低于高加索人，但尚未确定与台湾绝经后妇女的激素治疗（HT）相关的VTE的风险。方法？结果：从台湾的国家健康保险研究数据库，我们建立了1998年1月1日至2008年12月31日之间≥50年龄≥50岁的绝经后妇女的匹配队列（HT用户和非用户）。我们计算了VTE的2年发生率HT用户和非用户。基于倾向分数匹配，HT用户和非用户匹配1：1。 COX回归危险模型用于识别VTE的危险因素。我们最初确定了499,594个HT用户和424,963名非用户。 HT NORUSER之间的癌症和心血管事件百分比较高。在匹配后，VTE发病率为每10,000患者（调整后的危险比1.796,95％置信区间1.272-2.537）分别为4.4与2.6。 Cox回归危害模型表明，HT使用，年龄较大，恶性肿瘤，心力衰竭和最近的主要手术是VTE的独立风险因素。结论：虽然VTE的发病率在这一群体绝育妇女的群体中非常低，但口腔HT仍然与VTE的风险增加有关。因此，在规定后期妇女的口腔HT时，医生应该了解其他潜在的VTE风险因素。 （2015年CIRC; 79：1107-1114）

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