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首页> 外文期刊>Circulation journal >Fractional Flow Reserve With Dobutamine Challenge and Coronary Microvascular Endothelial Dysfunction in Symptomatic Myocardial Bridging
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Fractional Flow Reserve With Dobutamine Challenge and Coronary Microvascular Endothelial Dysfunction in Symptomatic Myocardial Bridging

机译：分数流量储备用抗症状心肌桥接的多巴酚丁胺挑战和冠状动脉微血管内皮功能障碍

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Background: ?Myocardial bridging (MB) results in compression of the coronary artery lumen in systole, extending into diastole with resultant hemodynamic alternation as reflected by fractional flow reserve (FFR). MB has also been associated with coronary endothelial dysfunction. The objective of this study was to investigate relationship between FFR with dobutamine challenge and coronary microvascular endothelial dysfunction in symptomatic MB. Methods and Results: ?Seventeen consecutive patients who had cardiac catheterization assessment of MB were enrolled. The patients were divided into 2 groups according to normal (% increase in coronary blood flow [%CBF] ≥50%, n=7) or impaired (%CBF 2=0.46, P=0.030; r2=0.52, P=0.018, respectively). Conclusions: ?Microvascular endothelial dysfunction was associated with decreased FFR at peak dobutamine stress in patients with symptomatic MB.??( Circ J ?2014; 78: 685–692)
机译：背景：α心肌桥接（MB）导致冠状动脉腔内的冠状动脉内腔压缩，延伸到舒张中，由作出血流动力学交替，如分数流量储备（FFR）反射。 MB也与冠状动脉内皮功能障碍有关。本研究的目的是调查FFR与毒性MB冠状动脉癌攻击和冠状动脉微血管内皮功能障碍的关系。方法和结果：涉及患有MB的心脏导管插入性评估的17名连续患者。根据正常（冠状动脉血流量≥50％，N = 7）或损害（％CBF 2 = 0.46，P = 0.030; R 2 = 0.52，p = 0.018）。结论：患有症状MB患者的峰值Dobutamine胁迫下的微血管内皮功能障碍与患者的峰值减少有关。??（Circ J？2014; 78：685-692）

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