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首页> 外文期刊>Circulation journal >Cataracts and Subclinical Carotid Atherosclerosis in Older Adults　― A Cross-Sectional Study of the HEIJO-KYO Cohort ―
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Cataracts and Subclinical Carotid Atherosclerosis in Older Adults　― A Cross-Sectional Study of the HEIJO-KYO Cohort ―

机译：老年人的白内障和亚临床颈动脉粥样硬化 - Heijo-Kyo Cohort的横断面研究 -

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Background: Decreased light reception because of cataracts leads to potential circadian misalignment, resulting in exacerbation of atherosclerosis; however, little is known about the association between cataracts and atherosclerosis in populations. Methods?and?Results: In this cross-sectional study, cataracts were graded using slit lamp biomicroscopy with the Lens Opacities Classification System III and carotid atherosclerosis was assessed based on carotid intima-media thickness (IMT) measured using ultrasonography of the common carotid artery in 442 elderly participants (mean age, 70.0 years). Cataract was defined as nuclear cataract grade ≥3.0, cortical cataract grade ≥2.0, or posterior subcapsular cataract grade ≥2.0 in both eyes. The mean and maximal carotid IMT was 0.86±0.15 mm and 1.07±0.29 mm, respectively. In multivariable analysis adjusted for potential confounders, the mean and maximal carotid IMT were significantly greater in the cataract group than in the non-cataract group by 0.04 mm (95% confidence interval (CI), 0.01–0.06) and 0.07 mm (95% CI, 0.01–0.12), respectively. Logistic regression analysis adjusted for confounders revealed a significantly higher odds ratio for carotid atherosclerosis (maximal carotid IMT ≥1.1 mm) in the cataract group than in the non-cataract group (odds ratio, 1.78; 95% CI, 1.14–2.78). Conclusions: Cataracts may be independently associated with subclinical carotid atherosclerosis in the elderly population, indicating a need for further prospective studies.
机译：背景：由于白内障导致潜在的昼夜活动，降低光接收，导致动脉粥样硬化的恶化;然而，对群体中白内障和动脉粥样硬化之间的关联知之甚少。方法？结果：在这种横截面研究中，使用狭缝灯生物显微镜进行白内障，透镜不透射率分类系统III和颈动脉粥样硬化是基于使用常见的颈动脉超声测量的颈动脉内膜介质厚度（IMT）进行评估在442名老年人（平均年龄，70.0岁）中。白内障被定义为核白内障≥3.0，皮质白内障等级≥2.0或双眼中的后亚片性白内障等级≥2.0。平均值和最大颈动脉IMT分别为0.86±0.15毫米和1.07±0.29 mm。在多变量分析中调整潜在混淆，白内障组的平均值和最大颈动脉IMT比非白内障组在0.04mm（95％置信区间（CI），0.01-0.06）和0.07mm（95％）中CI，0.01-0.12）分别。调整混淆的物流回归分析显示白内障组颈动脉粥样硬化（最大颈动脉IMT≥1.1mm）的显着较高的次数比非白内障组（差距率，1.78; 95％CI，1.14-2.78）。结论：白内障可能与年临床颈动脉粥样硬化有独立相关，表明需要进一步的前瞻性研究。

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