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首页> 外文期刊>Circulation journal >Age-Related Differences in the Clinical Characteristics and Treatment of Elderly Patients With Atrial Fibrillation in Japan　― Insight From the ANAFIE (All Nippon AF In Elderly) Registry ―
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Age-Related Differences in the Clinical Characteristics and Treatment of Elderly Patients With Atrial Fibrillation in Japan　― Insight From the ANAFIE (All Nippon AF In Elderly) Registry ―

机译：与日本心房颤动患者的临床特征和治疗有关的年龄相关差异 - 来自Anafie（所有Nippon AF在老年人）登记处的洞察力 -

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Background: Atrial fibrillation (AF) is increasing as the global population ages. Elderly AF patients (≥75 years) have a worse prognosis than younger patients, and effective management is often difficult due to multiple comorbidities. This analysis examined the age-related differences in clinical characteristics and treatment in real-world elderly Japanese AF patients. Methods?and?Results: The ANAFIE Registry is a multicenter, prospective, observational registry of 32,726 non-valvular AF patients aged ≥75 years. The present study assessed the age-related differences in baseline clinical status and anticoagulant therapy between age groups 75–80, 80–85, 85–90, and ≥90 years. The prevalence of persistent or permanent AF increased, and that of paroxysmal AF decreased, with increasing age (trend P0.0001). The risk of stroke, based on CHADSsub2/suband CHAsub2/subDSsub2/sub-VASc scores, and bleeding, based on HAS-BLED score, increased with age. Both warfarin and apixaban were used more often as age increased (trend P0.0001, for each), while other anticoagulants were used less. Anticoagulant doses were significantly lower in older patients. Conclusions: Permanent/persistent AF, comorbidities, and cardiovascular and bleeding risk all increased significantly with age. Furthermore, use of warfarin and apixaban increased with age, accompanied by a decrease in other oral anticoagulant usage.
机译：背景：心房颤动（AF）随着全球人口年龄而增加。老年AF患者（≥75岁）的预后比年轻患者更差，并且由于多种合并症，有效的管理往往难以困难。该分析检测了现实世界老年AF患者临床特征和治疗的年龄相关差异。方法？结果：ANAFIE登记处是一种多中心，前瞻性，观测的注册表32,726名非瓣膜AF患者≥75岁。本研究评估了年龄组之间的基线临床状态和抗凝血治疗的年龄相关差异75- <80,80- <85,85- <90和≥90年。持久性或永久性AF的患病率增加，阵发性AF的增加，随着年龄的增加而降低（趋势P <0.0001）。基于乍得 2 和cha 2 ds 2 -vasc评分，并且基于具有bld的分数，增加卒中风险随着年龄的增长。 Warfarin和Apixaban均以年龄的增加更频繁地使用（每次趋势P <0.0001），而其他抗凝血剂较少使用。老年患者的抗凝血剂量显着降低。结论：永久性/持久性AF，融合性和心血管和出血风险随着年龄的增长，全部增加。此外，随着年龄的增长，使用Warfarin和Apixaban的使用，伴随着其他口服抗凝血使用的减少。

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