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首页> 外文期刊>Case Reports in Nephrology >Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade
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Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

机译：急性肾脏损伤在患有确诊Covid-19患者的案例系列（2019年冠状病毒疾病）：血管紧张素转换酶2和肾素 - 血管紧张素系统封锁的作用

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The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage. There have been controversial hypotheses raised regarding the safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in COVID-19 (coronavirus disease 2019). We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Membrane-bound angiotensin-converting enzyme 2 (ACE2) has been implicated as the gateway for viral entry into the human cell in causing the infection. The factors contributing to acute kidney injury are diuretics, iodinated contrast administration, hemodynamic instability apart from ACE inhibitors, and angiotensin receptor blockers. The ACE inhibitors and ARBs were stopped in these patients due to acute kidney injury. We also discussed the role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with COVID-19 infection along with pathogenesis.
机译：肾素 - 血管紧张素系统在高血压，糖尿病和肾脏和心脏病中起着非常关键的作用。肾素 - 血管紧张素系统的阻断导致预防肾和心脏损伤的进展。关于Covid-19中的血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂的安全性提出了有争议的假设（Coronavirus疾病2019）。我们展示了四个患者（2名男子和2名女性; 1个白种人和3名非洲裔美国人;两名幸存下来，两名死亡）的案例系列与确认的Covid-19，患有呼吸系统症状和急性肾脏损伤，血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂。膜结合的血管紧张素转化酶2（ACE2）被牵引着作为病毒进入的孔进入人体细胞导致感染。有助于急性肾损伤的因素是利尿剂，碘化对比给药，除了ACE抑制剂的血液动力学不稳定性，和血管紧张素受体阻滞剂。由于急性肾损伤，在这些患者中停止了ACE抑制剂和ARBS。我们还讨论了ACE2和肾素 - 血管紧张素系统（RAS）封锁在Covid-19感染患者中的作用以及发病机制。

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