• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Case Reports in Nephrology >Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Sch?nlein Purpura Nephritis
【24h】

Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch–Sch?nlein Purpura Nephritis

机译：半乳糖缺乏IgA1沉积在透明细胞肾细胞癌相关的Henoch-Schonlein Purpura肾炎

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch–Sch?nlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and HSPN from secondary causes of glomerular IgA deposition. We report sequential kidney biopsies of a malignancy-associated HSPN, showing intense glomerular mesangial IgA deposition at the initial kidney biopsy and dramatic decrease in disappearance of glomerular deposits after tumor removal. We demonstrate that the glomerular IgA deposition contains Gd-IgA1, detected by immunostaining of KM55, with similar distribution and intensity to IgA. This suggests that renal Gd-IgA1 deposition may play a role in the pathogenesis of malignancy-associated HSPN.
机译：最近的研究表明，半乳糖缺陷的IgA1（GD-IgA1）在原发性IgA肾病（IgAn）和Henoch-SCH？NLein Purpura肾炎（HSPN）中起作用作用。此外，KM55的免疫染色，鉴定Gd-IgA1的抗体，可以有助于将原发性IgAn和Hspn与肾小球IgA沉积的二次原因分化。我们报告了恶性相关HSPN的顺序肾脏活组织检查，显示出在初始肾脏活检处的强烈肾小球Mesangial IgA沉积，并在肿瘤移除后肾小球沉积物消失的剧烈降低。我们证明肾小球IgA沉积含有通过KM55的免疫染色检测的GD-IgA1，其具有与IgA类似的分布和强度。这表明肾GD-IgA1沉积可能在恶性肿瘤相关HSPN的发病机制中发挥作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号