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首页> 外文期刊>Case Reports in Obstetrics and Gynecology >Squamous Carcinoma of the Neovagina after Male-to-Female Reconstruction Surgery: A Case Report and Review of the Literature
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Squamous Carcinoma of the Neovagina after Male-to-Female Reconstruction Surgery: A Case Report and Review of the Literature

机译：男性对女性重建手术后Neovagina的鳞状癌：文献报告和审查

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Squamous cell carcinoma (SCC) of the neovagina after genital reconstruction surgery is a rare occurrence with only very few cases published up to the present. We report a case of a 43-year-old transgender woman who developed neovaginal SCC 23 years after vaginoplasty. The patient tested positive for high-risk human papillomavirus (HPV). At the time of diagnosis, radiological investigations revealed already existing lymph node and osseous metastases. The treatment consisted of various cycles of chemotherapy and radiation therapy. Unfortunately, the formation of additional metastases, including cerebral, pulmonary, and hepatic metastases, could not be prevented. After comparing the literature on the topic, we conclude that neovaginal carcinoma often appears years and decades after genital reconstruction surgery. We therefore recommend the continuation of regular clinical follow-up for transgender women after postoperative follow-up is completed. With this approach, potential lesions may be detected at an earlier stage and a better outcome may be achieved. Follow-up should include neovaginal examination and cytological smear testing. At a later age, we recommend additional regular prostate-specific antigen (PSA) testing and digital rectal examination (DRE). Moreover, transgender women are advised to take part in mammography screening starting at the age of 50, especially when additional risk factors are present.
机译：鳞状细胞癌（SCC）在生殖器重建手术后稀有罕见，只有很少的案例发布到现在。我们举报了一个43岁的曲折妇女，在阴道成形术后23年开发了新世身科学SCC。患者测试高风险的人乳头瘤病毒（HPV）。在诊断时，放射性研究显示已存在淋巴结和骨质转移。治疗包括各种化疗和放射治疗循环。不幸的是，不能防止形成额外的转移，包括脑，肺和肝脏转移。在比较了文献之后，我们得出结论，在生殖器重建手术后常常出现多年和数十年的新毒性癌。因此，我们建议在术后随访后继续为跨性别妇女进行常规临床后续行动。利用这种方法，可以在较早的阶段检测潜在的病变，并且可以实现更好的结果。随访应包括Neovaginal检查和细胞学涂片测试。在后续时代，我们建议额外的常规前列腺特异性抗原（PSA）测试和数字直肠检查（DRE）。此外，建议跨性别妇女参加50岁时起的乳房X线摄影筛查，特别是当存在额外的危险因素时。

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