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首页> 外文期刊>Clinical Pediatric Endocrinology >Resumption of Puberty in Girls and Boys with Central Precocious Puberty After Withdrawal of Long-Term Therapy with LHRH-Analogue D-Ser-6-LHRH
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Resumption of Puberty in Girls and Boys with Central Precocious Puberty After Withdrawal of Long-Term Therapy with LHRH-Analogue D-Ser-6-LHRH

机译：利用LHRH - 模拟D-SER-6-LHRH撤回长期治疗后中央早熟青春期青春期恢复青春期

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There are few reports about reactivation of gonadal function and progress through puberty after withdrawal of therapy with LHRH-A in patients with central precocious puberty (CPP). Eight patients (5 females and 3 males) with CPP were treated with LHRH-A (D-Ser6-LHRH) with a dose of 10μg/kg by single or twice daily subcutaneous injections for periods ranging from 3 to 5.3 years. We have studied 30-day consecutive patterns of first morning voided urinary gonadotropin and ovarian hormone excretion in these patients during and after withdrawal of therapy with LHRH-A. During the treatment, the mean and maximum concentrations of urinary LH and FSH in 7 patients studied were low. After withdrawal of therapy, a rapid resumption of puberty was observed in 3 patients, who also had a hypothalamic hamartoma. In the remaining 5 patients with idiopathic CPP, the testes increased rapidly in size in one boy; but among 4 girls, only 1 had regular menstruation and the other 3 had irregular or no menstruation. The urinary patterns of these hormones did not return quickly to a pubertal pattern after withdrawal of treatment in these girls. This may be partly related to the long-term use of LHRH-A, but seems to be partly caused by psychological factors. These patients treated with long-term LHRH-A will head follow-up and evaluation of the reproductive function.
机译：关于加入治疗后患者在中央急诊青春期（CPP）患者患者患者后，少有关于加仑函数再激活和通过青春期的进展。用LHRH-A（D-SER6-LHRH）将8名患者（5名女性和3名患者）用LHRH-A（D-SER6-LHRH）处理，剂量为10μg/ kg，每日一次或两次皮下注射时间为3至5.3岁。我们在用LHRH-A撤回治疗期间和后，在这些患者中，在这些患者中进行了30天的连续尿尿激素和卵巢激素排泄。在治疗过程中，7例患者中的尿液LH和FSH的平均值和最大浓度低。在撤回治疗后，在3名患者中观察到青春期的快速恢复，患者也有一个下丘脑的Hamartoma。在剩余的5例特发性CPP患者中，该睾丸在一个男孩的规模上迅速增加;但在4个女孩中，只有1例常规月经，其他3个具有不规则或没有月经。这些激素的泌尿模式没有在这些女孩的治疗后迅速恢复到青春期模式。这可能与LHRH-A的长期使用部分相关，但似乎部分由心理因素造成的。这些患者用长期的LHRH-A治疗的患者将头部跟进和评估生殖功能。

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