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首页> 外文期刊>Cogent Chemistry >Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)
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Anti-inflammatory and anti-oxidant activities of ethanolic extracts of Tamarindus indica L. (Fabaceae)

机译：Tamarindus IndaN11的乙醇提取物的抗炎和抗氧化活性。（Fabaceae）

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Various parts of Tamarindus indica L are used to treat inflammatory disorders. This study evaluated the anti-inflammatory and antioxidant activities of the ethanolic extracts of the root and stem bark of the plant. The carrageenan-induced paw edema model of inflammation in chicks was used to assess anti-inflammatory activity. The phosphomolybdenum (PM) assay, 2, 2—diphenyl—1—picrylhydrazyl (DPPH) radical and hydrogen peroxide scavenging assays were used to investigate antioxidant potential. Total phenolic content was evaluated by the Folin–Ciocalteu method. Both stem bark and root extracts possessed similar total phenolic content (11–13?g/100?g AAE) and had comparable total antioxidant capacities (about 27?g/100?g GAE). However, the stem bark extract was a better scavenger of both DPPH radicals and hydrogen peroxide, with lower IC_(50) values than the root extract. In the anti-inflammation test, both extracts exhibited dose-dependent reduction of edema, similar to the standard drugs used. The root extract, with ED_(50) of 118.1?±?1.9 mg/kg, proved superior to the stem bark extract, whose ED_(50) was 154.5?±?2.6 mg/kg. The results showed that both stem bark and root extracts possess potent anti-inflammatory and anti-oxidant activity and confirm their use in folkloric medicine.
机译：Tamarindus Indema L的各个部分用于治疗炎症疾病。该研究评估了植物根系和茎树皮的乙醇提取物的抗炎和抗氧化活性。用雏鸟诱导的鸡肉诱导的爪子水肿模型用于评估抗炎活性。使用磷钼（PM）测定，2,2-二苯基-1-富铬（DPPH）自由基和过氧化氢清除测定来研究抗氧化潜力。通过Folin-Ciocalteu方法评价总酚醛含量。茎树皮和根提取物都具有相似的总酚含量（11-13〜100μlαgaae），并且具有可比的总抗氧化能力（约27μm≤g/100μlgae）。然而，茎树皮提取物是DPPH自由基和过氧化氢的更好的清除剂，具有比根提取物更低的IC_（50）值。在抗炎试验中，两种提取物都表现出剂量依赖性水肿，类似于所用的标准药物。根提取物，ED_（50）为118.1？±1.9 mg / kg，证明优于茎树皮提取物，其ED_（50）为154.5？±2.6mg / kg。结果表明，茎树皮和根提取物都具有有效的抗炎和抗氧化剂活性，并证实他们在民俗中使用。

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