• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and Experimental Vaccine Research >Cold chain time- and temperature-controlled transport of vaccines: a simulated experimental study
【24h】

Cold chain time- and temperature-controlled transport of vaccines: a simulated experimental study

机译：疫苗的冷链时间和温度控制运输：模拟实验研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose The objective of this research was to examine the cold chain temperature maintenance for the supply of vaccines and other biological products by pharmaceutical wholesaler. Materials and Methods In this study, six configurations using cold vaccine boxes or bags made with different materials, with and without insulation, of different sizes, and number of coolant-packs were used to simulate the configuration used by the pharmaceutical wholesalers for transportation of vaccine. Model vaccines (vial, n=10) were packed using these six configurations which then stored in an incubator at 38°C and monitored for 24 hours. Each configuration was tested repeatedly for 5 times. Results In term of compliance to 2°C–8°C, four out of six tested configurations are effective in cold chain transportation. The effectiveness is highly dependent on the type of passive containers used, size of cold boxes, insulation, and number of coolant-packs. The configuration with a larger polystyrene foam box with five coolant-packs maintained the required temperature up to 23 hours. In contrast, configurations using a polystyrene foam box with four coolant-packs and a large vaccine cold box with two coolant-packs failed to reach below 8°C throughout the 24 hours. Conclusion Packaging method, the material and size of the container could have a direct impact on the effectiveness of cold chain temperature maintenance. Polystyrene foam box, cold box with polyethylene interior lining and polypropylene insulation, a cooler bag with proper number of ice packs could be effectively used for transportation of vaccines within their respective transportation duration allowance.
机译：目的本研究的目的是通过药物批发商来检查用于供应疫苗和其他生物产品的冷链温度维护。本研究中的材料和方法，使用使用具有不同材料的冷疫苗盒或袋子的六种配置，具有不同尺寸，具有不同尺寸和冷却剂 - 包装的袋子来模拟药物批发商用于运输疫苗的配置。使用这六种配置填充模型疫苗（小瓶，N = 10），然后将其储存在38℃的培养箱中并监测24小时。每种配置都反复测试5次。结果符合2°C-8°C的符合性，六种测试配置中的四种是有效的冷链运输。有效性高度依赖于所用无源容器的类型，冷箱，绝缘和冷却剂包数的尺寸。具有五个冷却剂包装的较大聚苯乙烯泡沫箱的构型保持温度长达23小时。相比之下，使用具有四个冷却剂 - 包装的聚苯乙烯泡沫箱和具有两个冷却剂包装的大型疫苗冷箱的配置未在整个24小时内未能达到8℃以下。结论包装方法，容器的材料和尺寸可直接影响冷链温度维护的有效性。聚苯乙烯泡沫箱，冷箱用聚乙烯内衬和聚丙烯绝缘，具有适当数量的冰袋的冷却袋可以有效地用于在其各自的运输持续时间允许内运输疫苗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号