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首页> 外文期刊>Clinical & developmental immunology. >Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile
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Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile

机译：肺结核患者CD4 + CD25 + Foxp3 + T调节细胞频率增加及其与免疫内分泌剖面的关系

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Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation. Twenty-four age- and sex-matched healthy controls (HCo) were also included. Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo P < 0.05), showing even higher values at T2 (versus T0 P < 0.01) and T4 (versus T0 P < 0.001). While IL-6, IFN- γ , TGF- β (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9. Tregs correlated positively with IFN- γ ( R = 0.868, P < 0.05) at T2 and negatively at T4 ( R = ?0.795, P < 0.05). Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
机译：结核病（TB）是需要控制适当细胞免疫应答（IR）的主要健康问题。由于调节性T细胞（Tregs）在IR调节中相关，我们在整个结核病治疗过程中分析了Tregs变异及其与处理疾病免疫病理学的免疫内分泌介质变化的关系。队列由41名成年患者组成，其中20例完成治疗和随访。在治疗开始后，患者在诊断（T0）和2（T2），4（T4），6（T6）和9个月内进行。还包括二十四岁和性别匹配的健康控制（HCO）。 TB患者的Tregs（流式细胞术）在T0（与HCO P <0.05）上增加，在T2（与T0P <0.01）和T4（与T0 P <0.001）下表示较高的值。虽然IL-6，IFN-γ，TGF-β（ELISA）和皮质醇（电化学荧光，EQ）进行了增强，但DHEA-S（EQ）水平在T0相对于HCO，细胞因子和皮质醇恢复正常值在T9。 Tregs在T2的IFN-γ（R = 0.868，P <0.05）和T4的负相关，在T4（R = 0.795，P <0.05）上呈负相关。降低的促炎细胞因子以及接受特异性治疗的患者的Tregs的增加频率可能反映了这些细胞对随附的炎症的调节作用。

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