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首页> 外文期刊>Computational and mathematical methods in medicine >Analyzing the Correlation between the Level of Serum Markers and Ischemic Cerebral Vascular Disease by Multiple Parameters
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Analyzing the Correlation between the Level of Serum Markers and Ischemic Cerebral Vascular Disease by Multiple Parameters

机译：多种参数分析血清标志物水平与缺血性脑血管疾病之间的相关性

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Objective.To explore the serum markers associated with ischemic cerebral vascular disease (ICVD) and discuss their diagnostic value.Methods.Two hundred and eighty-eight patients with ICVD and one hundred and eighty healthy persons were enrolled as the case group and the control group, respectively. This paper then carried out the univariate and multivariate logistic regression analyses of their respective levels of serum markers, made combined analysis of related factors, and detected the diagnostic value.Results.Meta-analysis results showed that for ICVD patients the levels of CRP, S-100, TNF-α, HCY, NSE, and IL-6 were higher than those of the healthy persons, while the level of HDL was obviously lower than that of the healthy persons. The multivariate regression analysis indicated that the association between the level of HDL and TNF-αand the occurrence of ICVD was statistically significant (P<0.05). The area under the curves (AUC) of receiver operating characteristic (ROC) curve of HDL and TNF-αwas 0.916, with sensitivity of 90.91% and specificity of 76.47%.Conclusion.HDL has negative correlation with the occurrence of ICVD, while TNF-αwas positively correlated with it. The combination test of HDL and TNF-αcould raise the accuracy of ICVD diagnosis.
机译：目的。探索与缺血性脑血管疾病（ICVD）相关的血清标志物，并讨论其诊断价值..百八十八名患有ICVD和一百八十八个健康人的患者被称为案例组和对照组， 分别。本文对其各自的血清标记水平进行了单变量和多变量的物流回归分析，使相关因素的综合分析进行了组合分析，并检测了诊断价值。结果，分析结果表明，对于ICVD患者，用于ICVD患者的CRP，S水平。 -100，TNF-α，HCY，NSE和IL-6高于健康人的人，而HDL的水平明显低于健康人的水平。多元回归分析表明，HDL和TNF-α水平之间的关联和ICVD的发生是统计学意义（P <0.05）。 HDL和TNF-αwas0.916的接收器操作特征（ROC）曲线的曲线（AUC）下的区域，灵敏度为90.91％，特异性为76.47％.Conclusion.hdl与ICVD发生负相关，而TNF- αwas与它呈正相关。 HDL和TNF-α的组合试验可以提高ICVD诊断的准确性。

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