Use of Bioinformatics Technologies and Databases to Teach Analysis of Genetic Sequences to Undergraduate Students in Physics, Biotechnology, and Biology: The Specific Case of the SARS-CoV-2 Spike Protein

Michelle Abigail Fuentes-Acosta; Jorge Mulia-Rodríguez; Daniel Osorio-González

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Use of Bioinformatics Technologies and Databases to Teach Analysis of Genetic Sequences to Undergraduate Students in Physics, Biotechnology, and Biology: The Specific Case of the SARS-CoV-2 Spike Protein

机译：使用生物信息学技术和数据库来教导遗传序列对物理，生物技术和生物学本科生的分析：SARS-COV-2穗蛋白的特定情况

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Worldwide, the implementation of computational tools has allowed the advancement of our understanding, specifically, biotechnological information tools have made possible to tackle global challenges such as the COVID-19 pandemic; therefore, such tools are essential for science students. We propose an activity to teach the use of information and database biotechnologies and their utility for the alignment and comparison of sequences. We use as query sequence the corresponding to SARS-CoV-2 Spike protein in its closed state, and we compare it with 200 sequences obtained from the NCBI databases to identify the mutations and their domain. In the results, we show the frequency of the mutations, domain, and country of the isolated SARS-CoV-2 genome. The activity we propose is aimed at first-year undergraduate students in physics, biology, and biotechnology.

机译：在全球范围内，计算工具的实施允许我们理解的进步，具体而言，生物技术信息工具使得能够解决诸如Covid-19大流行之类的全球挑战;因此，这些工具对于科学学生至关重要。我们提出了一项活动，以教导信息和数据库生物技术的使用及其效用进行对准和比较序列。我们用作对应于其关闭状态的SARS-COV-2穗蛋白的查询序列，并将其与来自NCBI数据库获得的200个序列进行比较，以识别突变及其域。在结果中，我们展示了孤立的SARS-COV-2基因组的突变，域和国家的频率。我们提出的活动旨在瞄准物理，生物学和生物技术的一年本科生。

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《Creative Education》 |2021年第1期|共10页
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Michelle Abigail Fuentes-Acosta; Jorge Mulia-Rodríguez; Daniel Osorio-González;
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SpikeSARS-CoV-2Bioinformatic Technologies;

机译：尖峰 - 2bioInformatic技术;

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2. Assessing an effective undergraduate module teaching applied bioinformatics to biology students [J] . Andreas Madlung PLoS Computational Biology . 2018,第1期

机译：评估有效的本科生模块教学，向生物学专业的学生应用生物信息学
3. Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants [J] . Alice Massacci, Eleonora Sperandio, Lorenzo D’Ambrosio, Journal of Translational Medicine . 2020,第1期

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4. (1848) ROLE PLAYING GAMES IS A USEFUL TOOL TO LEARN AND TEACH CURRENT LEGAL REGULATION AND BIOSAFETY OF BIOTECHNOLOGY TO UNDERGRADUATE STUDENTS [C] . J.M. Becerril, I. Beguiristain, D. Docampo International Technology, Education and Development Conference . 2017

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5. Exploring genetics and developmental biology using multidimensional manipulatives and biotechnology laboratories. [D] . Saffron, Danida Dawn. 2001

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6. Data on the link between genomic integration of IS1548 and lineage of the strain obtained by bioinformatic analyses of sequenced genomes of Streptococcus agalactiae available at the National Center for Biotechnology Information database [O] . Sarah Khazaal, Rim Al Safadi, Dani Osman, 2020

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Use of Bioinformatics Technologies and Databases to Teach Analysis of Genetic Sequences to Undergraduate Students in Physics, Biotechnology, and Biology: The Specific Case of the SARS-CoV-2 Spike Protein

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