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首页> 外文期刊>Advances in Medicine >Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India
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Serum Vitamin D Level in Patients with Coronary Artery Disease and Association with Sun Exposure: Experience from a Tertiary Care, Teaching Hospital in India

机译：血清维生素D水平患者冠状动脉疾病和与阳光照射的关联：来自印度高等教育，教学医院的经验

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Background. Vitamin D, a fat-soluble vitamin, has various extraskeletal effects, and several human and animal studies have suggested that vitamin D deficiency may be a contributory factor in the pathogenesis of coronary artery disease (CAD). However, such studies in the Indian subcontinent are either lacking or have shown conflicting results. Methods. This was a descriptive cross-sectional study involving 121 patients with CAD from a tertiary care center and their 80 age-matched healthy controls. Serum vitamin D levels along with serum and urine chemistries were measured in both the groups. The average duration of sun exposure/day and use of sunscreen were also considered in the study cohort using a questionnaire. Serum vitamin D levels were categorized into deficient (30?nmol/lit), insufficient (30–75?nmol/lit), and sufficient (75?nmol/lit) groups. Results. Among the cases, 51.2% of the patients were vitamin D deficient and 44.6% patients had insufficient vitamin D levels, whereas among controls, 40% and 31% of the population had deficient and insufficient levels of vitamin D, respectively. However, the mean value of the serum vitamin D level was not statistically different in the cases as compared to that of the controls (34.06 vs 40.19?nmol/lit) (P=0.08). Corrected serum calcium (9.26 vs 9.59?mg%) (P≤0.0001) and serum albumin levels (4.21 vs 4.75 gm%) (P≤0.0001) were lower in the cases than those of the controls. The average sun exposure/day was higher among the cases than that among the controls (2.93 vs 1.85?hours) (P=0.001). Conclusion. Vitamin D deficiency is widely prevalent in Indian population despite abundant sunshine, and the duration of sun exposure is not correlated with serum vitamin D levels. Vitamin D deficiency is not associated with CAD. However, serum calcium is deficient in CAD patients as compared to the controls. Large-scale studies are required to explore the association further to evaluate the benefits of screening and correction of vitamin D deficiency in patients with CAD.
机译：背景。维生素D是一种脂溶性维生素，具有各种外核效应，几种人类和动物研究表明，维生素D缺乏可能是冠状动脉疾病发病机制（CAD）的贡献因素。然而，印度次大陆的这种研究要么缺乏或表现出相互矛盾的结果。方法。这是一个描述性横断面研究，涉及来自第三级护理中心的121名CAD患者及其80岁匹配的健康对照。在两种组中测量血清维生素D水平以及血清和尿液化学物质。使用问卷调查队列，还考虑了阳光暴露/日的平均持续时间和防晒霜。血清维生素D水平分为缺陷（<30？Nmol / lit），不足（30-75··苯酚/升），并且足够的（> 75·Nmol / Lit）组。结果。其中，51.2％的患者是维生素D缺乏，44.6％的患者的维生素D水平不足，而对照组，40％和31％的人群分别具有缺乏且不足的维生素D水平。然而，与对照的对照相比，血清维生素D水平的平均值在病例中没有统计学不同（34.06 vs 40.19？Nmol / lit）（p = 0.08）。校正血清钙（9.26 vs 9.59？mg％）（p≤0.0001）和血清白蛋白水平（4.21 vs 4.75 gm％）在比对照的情况下较低。在病例中的平均阳光暴露/日较高，而不是对照组（2.93 Vs 1.85？小时）（p = 0.001）。结论。维生素D缺乏在印度人群中广泛普遍，尽管阳光丰富，阳光暴露的持续时间与血清维生素D水平无关。维生素D不足与CAD无关。然而，与对照相比，血清钙缺乏CAD患者。需要大规模研究探讨协会进一步评估CAD患者维生素D缺乏症的筛选和纠正的益处。

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