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首页> 外文期刊>ACS Omega >Sol–Gel-Deposited Ti-Doped ZnO: Toward Cell Fouling Transparent Conductive Oxides
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Sol–Gel-Deposited Ti-Doped ZnO: Toward Cell Fouling Transparent Conductive Oxides

机译：溶胶 - 凝胶沉积的Ti-掺杂ZnO：朝向细胞污染透明导电氧化物

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Ti-doped ZnO thin films were obtained with the aim of tailoring ZnO film bioadhesiveness and making the optoelectronic properties of ZnO materials transferable to biological environments. The films were prepared on silicon substrates by sol–gel spin-coating and subsequent annealing. A Ti–O segregation limits the ZnO crystallite growth and creates a buffer out-layer. Consequently, the Ti-doped ZnO presents slightly increased resistivity, which remains in the order of 10–3 Ω·cm. The strong biochemical interference of Zn2+ ions released from pure ZnO surfaces was evidenced by culturing Staphylococcus epidermidis with and without the Zn2+ coupling agent clioquinol. The Ti-doped ZnO surfaces showed a considerable increase of bacterial viability with respect to pure ZnO. Cell adhesion was assayed with human mesenchymal stem cells (hMSCs). Although hMSCs find difficulties to adhere to the pure ZnO surface, they progressively expand on the surface of ZnO when the Ti doping is increased. A preliminary microdevice has been built on the Si substrate with a ZnO film doped with 5% Ti. A one-dimensional micropattern with a zigzag structure shows the preference of hMSCs for adhesion on Ti-doped ZnO with respect to Si. The induced contrast of surface tension further induces a cell polarization effect on hMSCs. It is suggested that the presence of Ti–O covalent bonding on the doped surfaces provides a much more stable ground for bioadhesion. Such fouling behavior suggests an influence of Ti doping on film bioadhesiveness and sets the starting point for the selection of optimal materials for implantable optoelectronic devices.
机译：通过剪裁ZnO膜生物粘附性并使ZnO材料的光电性能可转移到生物环境中的ZnO膜生物粘附性和ZnO膜的光电性能。通过溶胶 - 凝胶旋涂和随后的退火在硅基衬里上制备薄膜。 Ti-O偏析限制ZnO微晶生长并产生缓冲液外层。因此，Ti掺杂的ZnO具有略微增加的电阻率，其牵引量为10-3Ω·cm。通过用Zn2 +偶联剂CliOinol培养金葡萄球菌表皮，通过培养金葡萄球菌表皮释放的Zn2 +离子的强生化干扰。 Ti掺杂的ZnO表面相对于纯ZnO显着增加了细菌活力。用人间充质干细胞（HMSCs）测定细胞粘附。虽然HMSCS难以粘附在纯ZnO表面上的困难，但是当Ti掺杂增加时，它们逐渐膨胀在ZnO的表面上。在Si衬底上建立了初步微小，其中ZnO膜掺杂有5％Ti。具有Z字形结构的一维的微图案显示HMSCs在与Si相对于Si上的Ti掺杂ZnO上的粘附的偏好。表面张力的诱发对比度进一步诱导HMSC上的细胞偏振效应。建议在掺杂表面上的Ti-O共价键合的存在为生物粘度提供了更稳定的地面。这种污垢行为表明TI掺杂对薄膜生物粘合性的影响，并设定用于选择可植入光电器件的最佳材料的起点。

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