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首页> 外文期刊>ACS Omega >Aldehyde-Functionalized Magnetic Particles to Capture Off-Target Chemotherapeutic Agents
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Aldehyde-Functionalized Magnetic Particles to Capture Off-Target Chemotherapeutic Agents

机译：醛官能化磁性颗粒捕获脱靶的化学治疗剂

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Drug capture is a promising technique to prevent off-target chemotherapeutic agents from reaching systemic circulation and causing severe side effects. The current work examines the viability of using immobilized aldehydes for drug-capture applications via Schiff base formation between doxorubicin (DOX) and aldehydes. Commercially available pyridoxal-5′-phosphate (VB6) was immobilized on iron oxide nanoparticles (IONPs) to capture DOX from human serum. Leaching of VB6 persisted as a primary issue and thus various aldehydes with anchoring groups such as catechol, silatrane, and phosphonate esters have been studied. The phosphonate group-based anchor was the most stable and used for further capture studies. To improve the hydrophilic nature of the aldehydes, sulfonate-containing aldehydes and polyethylene glycols (PEGs) were investigated. Finally, the optimized functionalized iron oxide particles, PEGylated-IONP, were used to demonstrate doxorubicin capture from human serum at biologically relevant temperature (37 °C), time (30 min), and concentrations (μM). The current study sets the stage for the development of potential compact dimension capture device based on surface-anchorable polymers with aldehyde groups.
机译：药物捕获是一种有希望的技术，可防止脱靶疗化学治疗剂到达全身循环并导致严重的副作用。目前的工作检查使用固定的醛用于药物捕获应用的可行性通过多柔比蛋白（DOX）和醛之间的Schiff碱形成。将可商购的吡哆醛-5'-磷酸（VB6）固定在氧化铁纳米粒子（IONP）上以捕获人血清的DOX。 VB6的浸出持续为主要问题，因此已经研究了具有CateChol，硅烷和膦酸酯酯的锚定组的各种醛。膦酸酯基锚是最稳定的并且用于进一步捕获研究。为了改善醛的亲水性，研究了含磺酸盐的醛和聚乙二醇（PEG）。最后，优化的官能化氧化铁颗粒，Pegymated-IonP，用于在生物相关温度（37℃），时间（30分钟）和浓度（μm）中从人血清捕获多柔比星捕获。目前的研究设定了基于具有醛基的表面锚固聚合物的潜在紧凑尺寸捕获装置的阶段。

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