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首页> 外文期刊>ACS Omega >Fluorous-Phase Ion-Selective pH Electrodes: Electrode Body and Ionophore Optimization for Measurements in the Physiological pH Range
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Fluorous-Phase Ion-Selective pH Electrodes: Electrode Body and Ionophore Optimization for Measurements in the Physiological pH Range

机译：氟相离子选择性pH电极：电极体和离子载体优化，用于在生理pH范围内测量

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Because of their low polarity and polarizability, fluorous sensing membranes are both hydrophobic and lipophobic and exhibit very high ion selectivities. Here, we report on a new fluorous-membrane ion-selective electrode (ISE) with a wide sensing range centered around physiologically relevant pH values. The fluorophilic tris[perfluoro(octyl)butyl]amine (N[(CH_(2))_(4)R_(f8)]_(3)) was synthesized and tested as a new H~(+) ionophore using a redesigned electrode body that provides excellent mechanical sealing and much improved measurement reliability. In a challenging 1 M KCl background, these fluorous-phase ISEs exhibit a sensing range from pH 2.2 to 11.2, which is one of the widest working ranges reported to date for ionophore-based H~(+) ISEs. High selectivities against common interfering ions such as K~(+), Na~(+), and Ca~(2+) were determined (selectivity coefficients: logK H,?K) pot) = – 11.6; logK H,?Na) pot) = – 12.4; logK H,?Ca) pot) < – 10.2). The use of the N[(CH_(2))_(4)R_(f8)]_(3) ionophore with its ?(CH_(2))_(4)– spacers separating the amino group from the strongly electron-withdrawing perfluorooctyl groups improved the potentiometric selectivity as compared to the less basic tris[perfluoro(octyl)propyl]amine ionophore. The use of N[(CH_(2))_(4)R_(f8)]_(3) also made the ISE less prone to counter anion failure (i.e., Donnan failure) at low pH than the use of tris[perfluoro(octyl)pentyl]amine with its longer ?(CH_(2))_(5)– spacers, which more effectively shield the amino center from the perfluorooctyl groups. In addition, we exposed both conventional plasticized PVC-phase pH ISEs and fluorous-phase pH ISEs to 10% serum for 5 days. Results show that the PVC-phase ISEs lost selectivity while their fluorous-phase counterparts did not.
机译：由于它们的极性低，极性低，氟传感膜既是疏水性和脂肪酸，也具有非常高的离子选择性。这里，我们报告新的荧光膜离子选择电极（ISE），其围绕生理相关的pH值以围绕生理学相关的pH值为中心。荧光三[全氟（辛基）丁基]胺（N [（CH_（CH_（2））_（4）R_（4）R_（F8）] _（3））合成并用重新设计作为新的H〜（+）离子机器测试电极体提供出色的机械密封和更高的测量可靠性。在一个具有挑战性的1M KCl背景中，这些氟相的型是从pH 2.2-11.2的感测范围显示出迄今为止迄今为止基于离子载体的H〜（+）ises的最宽的工作范围之一。确定普通干扰离子的高选择性，例如K〜（+），Na〜（+）和Ca〜（2+）（选择性系数：Log K H，k）壶）= - 11.6; log k h，？na）pot）= - 12.4; log k h，？ca）pot）< - 10.2）。使用n [（ch_（ch_（ch_（ch_（ch_（ch_（ch_））_（4）r_（f8）] _（3）离子载体与其α（ch_（2））_（4） - 间隔物将氨基与强电子分离 - 与较低的碱性Tris [全氟（辛基）丙基]胺离子载体相比，取出全氟辛基提高电位选择性。使用n [（ch_（ch_（ch_（ch_（ch_（ch_（2））_（4）r_（f8）] _（3）也使ISE易于易于抵抗低pH值的阴离子失败（即，寡南部失败）而不是使用TRIS [Perfluoro （辛基）戊基]胺具有较长的α（CH_（2））_（5） - 间隔物，其更有效地屏蔽来自全氟辛基的氨基中心。此外，我们暴露了常规的增塑PVC相pH ises，氟相pH是10％血清5天。结果表明，PVC相是选择性丧失选择性，而他们的流频相同步并没有。

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