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首页> 外文期刊>African Journal of Biotechnology >Incidence and susceptibility pattern of clinical isolates from pus producing infection to antibiotics and Carica papaya seed extract
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Incidence and susceptibility pattern of clinical isolates from pus producing infection to antibiotics and Carica papaya seed extract

机译：从抗生素和Carica番木瓜种子提取物产生感染的临床分离株的发病率和敏感性模式

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摘要

The prevalence of bacterial pathogens isolated from pus producing infections (wound, eye and ear) randomly collected from the Medical Microbiology Laboratory of University College Hospital (UCH),Ibadan, Nigeria was determined. Their susceptibility to selected antibiotics and?Carica papaya?seed extracts was investigated. Bacterial pathogen identity was confirmed based on standard methods which included, Gram stain reaction, colonial morphology on media, lactose fermentation, catalase,oxidase,coagulase and indole tests. The antibiogram was carried out using standard disc agar diffusion method employing commercially prepared antibiotic disc (Abtek Limited) of amoxycillin (25mcg), co-trimoxazole (25 mcg), nitrofurantoin (300 mcg), gentamicin (10 mcg), nalidixic acid (30 mcg),ofloxacin (30 mcg), augmentin (30 mcg) and tetracycline (10 mcg). A total of 58 isolates were obtained out of which 31 were from wound, 12 from ear and 15 from eye. 41 of the isolates were recovered from adults, while 17 were from children.?Staphylococcus aureus?was found to be the most common organism recovered (51.7%), followed by?Klebsiella?spp. (11%),?Pseudomonas aeruginosa(11%),Proteus?spp. (6.9%) and?Escherichia coli?(3.4%). From wound swabs,?S. aureus?isolates was the highest (51.6%) followed by?Klebsiella?spp. (22.6%),Pseudomonas aeruginosa?and?Proteus?spp. (9.7% each) and?E. coli?(6.45%). In ear infection,?P. aeruginosa?accounted for 58.3%,?S. aureus?25%, while?Klebsiella?spp. and Proteus spp. accounted for 16.6% each. In eye infection,?S. aureus and Klebsiella?spp. were more frequently isolated with 73.3 and 20%, respectively. The antibiogram studies showed that all the organisms were highly sensitive to ofloxacin as follows:?S. aureus?(80%),?Klebsiella?spp. (100%),?P.?aeruginosa?(100%),?Proteusspp. (100%) and?E. coli?(100%) while?P. aeruginosa?(63.6%),?S. aureus?(76.6%) and?E. coli?(100%) were sensitive to gentamicin and?Klebsiella?spp. (18.2%) andProteus?spp. (25%) were resistant. The organisms were resistant to all the other antibiotics tested namely: amoxycillin, co-trimoxazole, nitrofurantoin, nalidixic, augmentin and tetracycline.?C. papaya?extract showed antimicrobial activity which compared favourably with the commercial antibiotic discs against the Gram positive and negative bacteria tested, except?Klebsiella?spp. The highest activity was demonstrated against?P. aeruginosa.?Key word:?Susceptibility, bacterial pathogens, pus, infection, antibiotics,?Caricapapaya?extract.
机译：确定了从大学学院医院（UCH），尼日利亚的大学学院医院（UCH）医学微生物实验室中随机收集的脓液中分离的细菌病原体（伤口，眼睛和耳朵）的细菌病原体。他们对所选抗生素和？Carica Papaya的易感性研究了种子提取物。基于标准方法证实了细菌病原体特征，克染色反应，培养基，乳糖发酵，过氧化氢酶，氧化酶，凝固酶和吲哚试验中的殖民形态。使用使用的标准盘琼脂扩散方法进行，采用氨基甲苯胺（25mcg），共析氧唑（25mcg），呋喃脲（300mcg），庆大霉素（10mcg），萘啶酸（30 MCG），氧氟沙星（30mcg），蔚蓝素（30mcg）和四环素（10mcg）。总共58个分离物获得，其中31中来自伤口，12来自耳朵和15只眼睛。从成年人中回收了41个分离物，而17则来自儿童。？发现是药金黄色葡萄球菌，其是最常见的有机体（51.7％），其次是αklebsiella？spp。 （11％），？假单胞菌铜绿假单胞菌（11％），Proteus？SPP。 （6.9％）和？大肠杆菌？（3.4％）。从伤口拭子，Δs。金黄色葡萄球菌？分离物是最高的（51.6％），然后是？克莱布拉？SPP。 （22.6％），假单胞菌铜绿假单胞菌？和蛋白质？SPP。 （每次9.7％）和？e。大肠杆菌？（6.45％）。在耳朵感染中，？p。铜绿假单胞菌？占58.3％，人。金黄色葡萄球菌？25％，而克莱布拉？SPP。和proteus spp。每个人都占16.6％。在眼睛感染，？s。金黄色葡萄球菌和克莱斯尼拉？SPP。更频繁地分离73.3和20％。抗诊断研究表明，所有生物体对氧氟沙星非常敏感，如下：ΔS。金黄色葡萄球菌？（80％），？克莱布拉？SPP。 （100％），？p.?Eeruginosa ?(100%) ,?proteusspp。 （100％）和？e。大肠杆菌？（100％）而？p。铜绿假单胞菌？（63.6％）,?。金黄色葡萄球菌（76.6％）和？e。大肠杆菌？（100％）对庆大霉素和克里斯艾拉敏感？SPP。 （18.2％）&proteus？spp。 （25％）是抗性的。生物体对所有其他抗生素造成的，即：阿莫西霉素，共析唑，呋喃脲，萘啶，杜梅蛋白和四环素。番木瓜？提取物显示出抗微生物活性，其与商业抗生素椎间盘相比比较克里克阳性和阴性细菌，除了？Klebsiella？SPP。最高的活动是针对Δp的。 eruginosa.?key字：？易感性，细菌病原体，脓液，感染，抗生素，？caricapapaya？提取物。

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