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首页> 外文期刊>African Journal of Biotechnology >Effects of varying levels of n-6:n-3 fatty acid ratio on plasma fatty acid composition and prostanoid synthesis in pregnant rats
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Effects of varying levels of n-6:n-3 fatty acid ratio on plasma fatty acid composition and prostanoid synthesis in pregnant rats

机译：不同水平的N-6：N-3脂肪酸比对孕血浆脂肪酸组成和前列腺合成的影响

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This study investigated the effects of? varying dietary levels of n-6:n-3 fatty acid ratio on plasma fatty acid composition and prostanoid synthesis in pregnant rats. Four? groups consisting of seven rats per group? of? non pregnant? rats? were fed diets with either a very low?n-6:n-3?ratio of 50% soybean oil (SBO): 50% cod liver oil (CLO) 1:1 group , a low? ratio of? 84% SBO: 16% CLO? 6:1 group, a high ratio of 96% SBO: 4% CLO 30:1 group and control group was given only rat chow diet. Blood samples were taken at day 15 post mating and the plasma was analyzed for fatty acid profile, specifically the?n-6:n-3?fatty acid ratio and? prostaglandins F2α and E2. The?n-3?polyunsaturated fatty acids??(PUFA)?in plasma of group? 1:1? were significantly (P < 0.05) higher than the other groups, while the n-6:n-3 fatty acid ratio was significantly lower. The total?n-6?PUFA was significantly higher (P < 0.05) in group? 30:1 as compared to the control and 1:1? groups. The total PGF2α and PGE2 were significantly higher (P < 0.05) in group? 30:1 rats fed? a diet high in n-6 or?n-6:n-3?fatty acids. The diet higher in?n-6?fatty acids appear to increase arachidonic acid( AA) and prostaglandins synthesis in plasma of rats. PGE2 productions in plasma were significantly lower in rats fed diets with a lower dietary ratio of?n-6:n-3?fatty acids than in those fed diets with a higher dietary ratio. Regression analysis revealed a significant positive correlation between PGF2α and PGE2 and the ratio of?n-6:n-3, and significant positive correlation between different ratio n-6:n-3 on fatty acid plasma compstion and PGF2α and PGE2 concentration on plasma. These results demonstrated that the dietary ratio of?n-6:n-3?modulates PGF2α and PGE2 production. The?n-6:n-3?fatty acid ratio significantly affected plasma fatty acids profile and prostaglandin synthesis in pregnant rat.
机译：本研究调查了效果？改变膳食水平的N-6：N-3脂肪酸组合物与孕妇脂肪酸组成和前列腺合成的N-3脂肪酸比。四？每组七只大鼠组成的团体？的？怀孕了吗？老鼠？用非常低的饮食喂食饮食Δn-6：n-3？比例为50％豆油（Soybean油（Soybean）：50％Cod肝油（CLO）1：1组，低？比例？ 84％SBO：16％Clo？ 6：1组，高比率为96％SBO：4％CLO 30：1组和对照组仅给予大鼠味道饮食。在第15天拍摄血液样品后，交配后15天，分析血浆以用于脂肪酸谱，特别是αN-6：N-3？脂肪酸比和？前列腺素F2α和E2。 ？n-3？多不饱和脂肪酸??（pufa）？在血浆中的血浆？ 1：1？显着比其他基团显着（P <0.05），而N-6：N-3脂肪酸比显着降低。总数？N-6？PUFA在组中显着高（P <0.05）？ 30：1与对照和1：1相比？团体。 PGF2α和PGE2总数显着高（P <0.05）？ 30：1大鼠喂食？在N-6或β3：N-3？脂肪酸中饮食。饮食更高？脂肪酸似乎增加了大鼠血浆中的花生酸（AA）和前列腺素合成。大鼠血浆中血浆中的PGE2在喂食饮食比饮食比的饮食比例下的饮食中的血浆显着降低，比在喂养饮食比例的那些饮食中的饮食中的饮食比例。回归分析显示PGF2α和PGE2之间的显着正相关和αN-6：N-3的比例与不同比率N-6：N-3对脂肪酸等离子体复合物和PGF2α的显着阳性相关性等离子体上的PGF2α和PGE2浓度。 。这些结果表明？N-6：N-3的膳食比例是调节PGF2α和PGE2的生产。 αN-6：N-3？脂肪酸比显着影响孕鼠血浆脂肪酸谱和前列腺素合成。

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